Tablet powder containing 100mg of promazine hydrochloride is ground to a paste with 10 ml of 2 M HCl. The paste is then diluted with 300 ml of water, shaken for 15 min and finally made up to 500 ml. A portion of the extract is filtered. Then, 5 ml of the filtrate is taken and diluted to 200 ml with 0.1 M HCl. – Absorbance reading=0.855 is read at a wavelength wavelength of 251 nm – a (1%, 1 cm) value of promazine.HCl at 251 nm=950 – Stated content of promazine.HCl per tablet=60 mg – Weight of 24 tablets=1.500g – Weight of tablet powder taken for assay=180 mg expected content in tablet taken is: 172.8 mg 1000mg 100 mg 100g Concentration in diluted tablet extract is: 0.1g/mL 0.9 g/100ml 1.11 g/mL 0.9 mg/100ml Concentration in original tablet extract is: 36g/mL 36 mg/100ml 19.38 mg/100ml 16.15 mg/mL Amount of promazine.HCl in original extract is: 172.8mg 180mg/100ml 96.90mg 180mg percentage of stated content 99.1 % 96% 80.75mg/100ml 104.2%
Tablet powder containing 100mg of promazine hydrochloride is ground to a paste with 10 ml of 2 M HCl. The paste is then diluted with 300 ml of water, shaken for 15 min and finally made up to 500 ml. A portion of the extract is filtered. Then, 5 ml of the filtrate is taken and diluted to 200 ml with 0.1 M HCl. – Absorbance reading=0.855 is read at a wavelength wavelength of 251 nm – a (1%, 1 cm) value of promazine.HCl at 251 nm=950 – Stated content of promazine.HCl per tablet=60 mg – Weight of 24 tablets=1.500g – Weight of tablet powder taken for assay=180 mg expected content in tablet taken is: 172.8 mg 1000mg 100 mg 100g Concentration in diluted tablet extract is: 0.1g/mL 0.9 g/100ml 1.11 g/mL 0.9 mg/100ml Concentration in original tablet extract is: 36g/mL 36 mg/100ml 19.38 mg/100ml 16.15 mg/mL Amount of promazine.HCl in original extract is: 172.8mg 180mg/100ml 96.90mg 180mg percentage of stated content 99.1 % 96% 80.75mg/100ml 104.2%
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question
Tablet powder containing 100mg of promazine hydrochloride is ground to a paste
with 10 ml of 2 M HCl. The paste is then diluted with 300 ml of water, shaken for
15 min and finally made up to 500 ml. A portion of the extract is filtered. Then,
5 ml of the filtrate is taken and diluted to 200 ml with 0.1 M HCl.
– Absorbance reading=0.855 is read at a wavelength wavelength of 251 nm
– a (1%, 1 cm) value of promazine.HCl at 251 nm=950
– Stated content of promazine.HCl per tablet=60 mg
– Weight of 24 tablets=1.500g
– Weight of tablet powder taken for assay=180 mg
expected content in tablet taken is:
172.8 mg
1000mg
100 mg
100g
Concentration in diluted tablet extract is:
0.1g/mL
0.9 g/100ml
1.11 g/mL
0.9 mg/100ml
Concentration in original tablet extract is:
36g/mL
36 mg/100ml
19.38 mg/100ml
16.15 mg/mL
Amount of promazine.HCl in original extract is:
172.8mg
180mg/100ml
96.90mg
180mg
percentage of stated content
99.1 %
96%
80.75mg/100ml
104.2%
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