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Specific inhibitors of dyneins have yet to be discovered. When they are discovered, how would they most likely affect cells?
Reduce retrograde transport of endosomes |
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Decrease pseudopod formation in amoeboid cells |
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Increase cell size |
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Decrease contraction of skeletal muscle |
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- The pathway shown below is used by a fungus to create Arginine from a precursor starter molecule. A nonsense mutation occurs in the gene that encodes enzyme 2. This fungus is grown on media that only contains the precursor. Discuss the effects of this mutation on:(i) The function of Enzyme 2 (ii) The potential of the fungus to produce OrnithineAmoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit ADP, and activate myosin II) is found toward the rear of the cell. Based on your…Amoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit cofilin/ADP, and activate myosin II) is found toward the rear of the cell. Based on your…
- The most selectively toxic antibacterial agents are those that interfere with bacterial cell wall synthesis. This is because ________. Group of answer choices bacterial cell wall synthesis is easily inhibited whereas eukaryotic cell wall synthesis is more resistant to the actions of the drugs bacterial cell walls have a unique structure not found in eukaryotic host cells eukaryotic cells do not take up the drugs eukaryotic cells inactivate the drugs before they can do any damagePut the following steps for the outline of the growth factor signaling pathway in order: Map Kinase Kinase is Phosphorylated Proteins involved in gene transcription are activated Growth factor binds to its receptor in the cytoplasmic membrane Receptor recruits adaptor protein and GEF Autophosphorylation of tyrosine residues on the receptor Structural change of the receptor activates Tyrosine Kinase Map Kinase Kinase Kinase is phosphorylated Ras, a small GTPase, is activated by the exchange of GTP for GDP Map Kinase is Phosphorylated Map Kinase enters the nucleusA Simple Targeting Model describes which mechanism of cellular transport targeting? motor molecules targeted by changes in subdomain phosphatase and kinase concentrations cargo proteins targeted by changes in subdomain phosphatase and kinase concentrations random binding of cargo to cellular subdomains random binding of motor molecules to specific subcellular regions