Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism.   Use the image to answer the question. Which conclusion can you draw based on the diagram?   A. The mutation changed the amino acid sequence during the translation step.   B. A mutation caused the information in DNA to change during the transcription step.   C. A change in the DNA sequence can be carried over to the translation and transcription steps.   D. The change that affected the translation and transcription steps does not affect the organism.

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
Problem 15P: Recombination in Immunoglobulin Genes If recombination between a Vkand Jkgene formed a CCA codon at...
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Sickle cell anemia is a disease caused by a mutation at the genotypic level. A person with two copies of the gene has the disease, but a person with one copy of the gene does not have the disease. The diagram shows how this mutation affects an organism.

 

Use the image to answer the question.

Which conclusion can you draw based on the diagram?

  •  
    A.

    The mutation changed the amino acid sequence during the translation step.

  •  
    B.

    A mutation caused the information in DNA to change during the transcription step.

  •  
    C.

    A change in the DNA sequence can be carried over to the translation and transcription steps.

  •  
    D.

    The change that affected the translation and transcription steps does not affect the organism.

Wild-type B-globin
Sickle-cell B-globin
Wild-type B-globin DNA
CTC
GAG
Mutant B-globin DNA
5'
13'
3'
31
CAC
15'
5
GTG
13'
MRNA
5'1
MRNA
5'
GAG
13'
GUG
13'
Normal hemoglobin
Sickle-cell hemoglobin
Val
Glu
s in
Transcribed Image Text:Wild-type B-globin Sickle-cell B-globin Wild-type B-globin DNA CTC GAG Mutant B-globin DNA 5' 13' 3' 31 CAC 15' 5 GTG 13' MRNA 5'1 MRNA 5' GAG 13' GUG 13' Normal hemoglobin Sickle-cell hemoglobin Val Glu s in
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