describe SARS-CoV2 Spike Protein
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describe SARS-CoV2 Spike Protein
The world is battling with Coronavirus disease (Covid-19) which is caused by the SARS-CoV 2 virus. It affects different people in different ways and the symptoms range from fever, cough, loss of taste and smell to difficulty breathing and chest pain. SARS CoV 2belongs to the family of Severe Acute Respiratory Syndrome or SARS which is a viral respiratory disease and is caused by the SARS-associated coronaviruses. First identified in February 2003 and the second outbreak was reported in Dec 2019 that we are still struggling with.
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- Name conditions caused by abnormalities of vertical linkages and horizontal (lateral) linkages in RBC transmembrane and cytoskeletal proteins.Calculate the specificity factor (a) of the interaction between the ACE2 protein and SARS-CoV-2 variant spike proteins at [ACE2] = 1 nM and 10nM. Show work plsPlease help explain Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a carboxypeptidase that degrades angiotensin II, thereby improving the pathologies of cardi- ovascular disease or acute lung injury. Here we show that B38-CAP, an ACE2-like enzyme, is protective against SARS-CoV-2-induced lung injury. Endogenous ACE2 expression is downregulated in the lungs of SARS-CoV-2-infected hamsters, leading to elevation of angiotensin II levels. Recombinant Spike also downregulates ACE2 expression and worsens the symptoms of acid-induced lung injury. B38-CAP does not neutralize cell entry of SARS- CoV-2. However, B38-CAP treatment improves the pathologies of Spike-augmented acid- induced lung injury. In SARS-CoV-2-infected hamsters or human ACE2 transgenic mice, B38-CAP signi!cantly improves lung edema and pathologies of lung injury. These results provide the !rst in vivo…
- Even single point mutations can have a significant effect on protein function. Describe how point mutations in the SARS-CoV2 spike protein might affect its function.Define α6β4 integrinSequence A: TCT/ TCC/ CTC/ CTA/ AAC/ GTT/ CAA/ CCG/ GTT/ CTT/ AAT/ CCG/ CCG/ CCA/ GGG/ CCC/ CGC/ CCC/ TCA/ GAA/ GTT/ GGT AGA Sequence B: TCA/ GAC/ GTT/ TTT/ GCC/ CCG/ TAA/ CAA/ CTT/ GTT/ ACA/ ACA/ TGG/ TCA/ TAA/ ACG/ TCA/ GAG/ ATG/ GTC/ AAT/ CTC/ TTA/ ATG/ ACT Sequence C: TAT/ ATA/ CAT/ GTA/ AAC/ ACA/ TAC / TCA/ GTG/ GAC/ CAA/ CTC/ AAC/ ATA/ AAC/ CAA/ ACA/ CCG/ CTC/GCG/ CCG/ AAA/ AAG/ ATA/ TGG STEP 1: Transcribe each of the 3 DNA sections into nRNA. Write out the complementary CODONS directly below the DNA strands. STEP 2: Clearly identify the three fragments as the FIRST, SECOND and THIRD fragments by clearly labeling any obvious PROMOTERS, START and STOP codons. STEP 3: Number the the START codon #1 and number the codons in the correct order until the STOP codon is reached. STEP 4: Codons 14- 64 (including 14 & 64) represent an intron. Draw a single red line through these codons to indicate that they will NOT be translated. STEP 4: In the space provided, write out the…
