Select the statements that describe the properties and mechanism of the leucine transporter. Since the Vmax for all three substrates is lower in the absence of Na+, the leucine transporter cotransports Na+ and the amino acid. The higher K, for D-leucine suggests that the leucine transporter binding site affinity depends on the orientation of groups on the x carbon of the amino acid. Since the K, for each substrate remains approximately the same in the presence and absence of Na+, the leucine transporter does not require Na+ to transport amino acids. The high Vmax for D-leucine suggests that the leucine transporter binding pocket preferentially binds D-leucine over L-leucine and L-valine. The similar K, values for L-leucine and L-valine suggest that the binding site in the leucine transporter recognizes the side chains of both amino acids
Select the statements that describe the properties and mechanism of the leucine transporter. Since the Vmax for all three substrates is lower in the absence of Na+, the leucine transporter cotransports Na+ and the amino acid. The higher K, for D-leucine suggests that the leucine transporter binding site affinity depends on the orientation of groups on the x carbon of the amino acid. Since the K, for each substrate remains approximately the same in the presence and absence of Na+, the leucine transporter does not require Na+ to transport amino acids. The high Vmax for D-leucine suggests that the leucine transporter binding pocket preferentially binds D-leucine over L-leucine and L-valine. The similar K, values for L-leucine and L-valine suggest that the binding site in the leucine transporter recognizes the side chains of both amino acids
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 5.4P
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Transcribed Image Text:To gain insight into the mechanism of the leucine transporter in intestinal epithelial cells, the rate of uptake of L-leucine,
D-leucine, and L-valine was assayed in the presence and absence of Nat. The results of rate measurements are given in the table.
Uptake in presence of
Na+
Substrate Vmax
L-Leucine 420
D-Leucine 310
L-Valine 225
K₁ (MM)
0.24
4.7
0.31
Uptake in absence of
Na+
Vmax
23
5
19
K₁ (MM)
0.24
4.7
0.31
Select the statements that describe the properties and mechanism of the leucine transporter.
Since the Vmax for all three substrates is lower in the absence of Na+, the leucine transporter cotransports Na+ and the
amino acid.
The higher K for D-leucine suggests that the leucine transporter binding site affinity depends on the orientation of
groups on the x carbon of the amino acid.
Since the K, for each substrate remains approximately the same in the presence and absence of Na+, the leucine
transporter does not require Na+ to transport amino acids.
The high Vmax for D-leucine suggests that the leucine transporter binding pocket preferentially binds D-leucine over
L-leucine and L-valine.
The similar K, values for L-leucine and L-valine suggest that the binding site in the leucine transporter recognizes the
side chains of both amino acids.
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