Respiratory epithelial cells are involved in mucus maintenance within the airway. Explain the roles of pumps, channels, and carriers in this process – emphasize CFTR’s role in chloride passage, and how chloride triggers water movement which maintains the mucus fluidity in the airway.

Respiratory epithelial cells are involved in mucus maintenance within the airway. Explain the roles of pumps, channels, and carriers in this process – emphasize CFTR’s role in chloride passage, and how chloride triggers water movement which maintains the mucus fluidity in the airway.

Biomedical Instrumentation Systems

1st Edition

ISBN:9781133478294

Author:Chatterjee

Publisher:Chatterjee

Chapter11: Instrumentation In Respiration

Section: Chapter Questions

Problem 12P

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Concept explainers

Osmosis

In simple words, osmosis is the slow, gradual movement of a liquid through a membrane. But there are nuances to this process. For instance, there has to be an imbalance in the distribution of solute in the liquid on either side of the membrane, which has to be semipermeable. The liquid in the region with a lower solute concentration moves to the region with a higher concentration, thereby displacing the solution in the process. The objective is to equalize the concentration of molecules on both sides of the membrane; the displacement of liquid can be viewed as a byproduct of this equalization. Since there is no energy required to carry osmosis, it is considered a passive process.

Question

Respiratory epithelial cells are involved in mucus maintenance within the airway. Explain the
roles of pumps, channels, and carriers in this process – emphasize CFTR’s role in chloride
passage, and how chloride triggers water movement which maintains the mucus fluidity in the
airway.

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