Researchers discovered recently that the sole functionof the SRY protein is to activate an autosomal genecalled Sox9 in the presumptive gonad (before it has“decided” to become a testis or an ovary).a. What would be the sex of an XY individual homozygous for nonfunctional mutant alleles of Sox9?Explain.b. Given your answer to part (a), why is SRY, ratherthan Sox9, considered the male determining factor?(Hint: What do you think would happen if you didan experiment like the one in the Fast Forward BoxTransgenic Mice Prove That SRY Is the MalenessFactor, except that you used a Sox9 transgeneinstead of SRY?)

Human Biology (MindTap Course List)
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Chapter20: Chromosomes And Human Genetics
Section: Chapter Questions
Problem 2CT: Human sex chromosomes are XX for females and XY for males. a. With respect to an X-linked gene, how...
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Researchers discovered recently that the sole function
of the SRY protein is to activate an autosomal gene
called Sox9 in the presumptive gonad (before it has
“decided” to become a testis or an ovary).
a. What would be the sex of an XY individual homozygous for nonfunctional mutant alleles of Sox9?
Explain.
b. Given your answer to part (a), why is SRY, rather
than Sox9, considered the male determining factor?
(Hint: What do you think would happen if you did
an experiment like the one in the Fast Forward Box
Transgenic Mice Prove That SRY Is the Maleness
Factor, except that you used a Sox9 transgene
instead of SRY?)

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