Answered: reference to table 1, discuss the…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Related questions

Concept explainers

Question

A range of substituted biphenyls have been evaluated as antagonists of the GPCR neurokinin-1 (NK1) , a target for the treatment of cancer chemotherapy endured nausea and vomiting. With reference to table 1, discuss the structure activity relationships related to the nature of the substituent R1 and linker group L. In your answer, aim not just to identify trends, but to give possible explanations to them. Include as much detail as possible.

Table 1. Effect of biphenyl substituent R¹ and linker group L on human NK₁ inhibitory
activity.
R¹
CF3
R¹
hNK₁ K₁
hNK₁ K₁
Com-
pound
(nM)
(nM)
1
51
295
2
17
>10,000
22
562
45
68
> 10,000
1,380
3
4
5
H
CH3
CI
Br
H
O
www
O
w
O
L
m
CF3
Com-
pound
6
7
8
9
10
R¹
H
H
H
H
H
L
2X
ex
NN
www.
mj
IZ ₂₂
O

Expert Solution

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions