Recent research showed that glucocorticoid receptor expression increased in rat hippocampus follow their exposure to loud noise. Based on what we learned, please predict how this would affect the blood corticosterone level in the noise-exposed rats. a.) increase b.) decrease c.) no change

1A. If Creb upregulates gene T with acetylcholine stimulation, what happens to T when cAMP phosphodiesterase is always active compared to normal? 1B. If Creb normally upregulates expression of gene Y with adrenaline stimulation, what happens to gene Y if PKA has a nonfunctional NLS compared to normal signaling?    Choices are: A. Stays the same B. Decreased expression C. Increased expression

Which of the following would you expect to happen if amino acids 579 to 582 (YIYV) in the PDGF-Beta receptor were exchanged with amino acids 992 to 995 (YLIP) from the EGF receptor to give PDGF (YLIP) and EGF (YIYV) (Select all that apply)? (A) (B) PDGF-B receptor Src $8 & P 579 P 581 YIYV PI3KY P 740 YMDM NCK-a P 751 YVPM P 771 YMAP GAP NCK-B SHP2 PLC-y P P 1009 YTAV 1021 YIIP ala 845 YHAE 992 YLIP P 1045 YSSD 1068 YINQ 1086 YHNK 1148 YQQD P 1173 YLRV P P P P P EGF receptor STAT3/5 PLC-y Shc Cbl JAK2 Grb2 STAT3/5 Shc SHP1 PTP1

It is important for the cell to be able to terminate responses, and diminish responsiveness to prevent overstimulation.  Cells have different mechanisms for this. One such mechanism is receptor down regulation. a.) Down regulation describes a decrease in the availability of hormones or neurotransmitters that bind to receptors on the surface of target cells, making the cells less likely to be stimulated.   b.) Down regulation describes glycosylation of receptor proteins receptors on the surface of target cells in order to decrease the selectivity of ligand binding, making the cells less sensitive to a hormone or neurotransmitter.   c.) Down regulation describes a decrease in the number of receptors on the surface of target cells, making the cells less sensitive to a hormone or neurotransmitter.