Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Q. Both histone deacetylase (HDAC) and Xist would be on a list of genes involved in X chromosome inactivation.
In which of the following ways would the histone deacetylase gene be similar to the Xist gene?
A. They would both be transcribed.
B. They would both be translated.
C. They would both undergo intron splicing.
D. They would both be transported to the cytoplasm after transcription.
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- A. Identify the mutation(s) that lead to the most loss in transcriptional activity, and discusswhether those match expectations based on the consensus sequence for the Initiator.B. Hypothesize a molecular mechanism to explain how the mutations identified in Part Aresult in loss of transcription activity.C. Identify whether any mutations cause transcription to initiate from a different positionthan wild-type, and provide a brief explanation as to why that occurs for those mutantcore promoters. THIS IS A PRIMER EXTENSION ASSAYarrow_forward. Gene expression in mammals can be increased by which of the following mechanisms? X-chromosome inactivation (as in the case of the female tortoiseshell cat) histone dephosphorylation histone methylation histone deacetylation E. histone phosphorylationarrow_forwardCan you explain it?arrow_forward
- fill in the blank: a. lincRNA plays a role in regulating ___ making genes but they themselves are encoded in the genome that is considered _____ DNA. b. The most well known example of RNA regulating the expression of DNA is the production of the ___ that coats one copy of the X chromosome in a female forming the ____.arrow_forwardMatch whether the protein binds directly or indirectly (assuming it does) to DNA and whether to the enhancer or promoter. Items may be matched to multiple choices and not all choices will be used. 1. Directly to enhancer Repressors 2. Directly to promoter Activators 3. Indirectly to enhancer TBP associated factors 4. Indirectly to promoter >arrow_forwardQuestion 14 ZORANG PENYATA G O a polar head and tail TANAMAN A phospholipid molecule is best described as: O a polar head and nonpolar tail a nonpolar head and tail ****** an adenine with three phosphatesarrow_forward
- Can you explain?arrow_forwardA. Based on this data, draw a conclusion about the promoter elements that Caudal specifically upregulates. B. Dr. Juven-Gershon also tested Caudal activation of core promoter sequences from twoother genes. Similar to the first experiment, one was DPE-dependent (from the E74Bgene), and the other was TATA-dependent (from the Adh gene). However, these two corepromoters lacked the BREU motif. The results from these additional core promoters areshown below. Based on these results and those shown above, propose a hypothesis thatexplains the differences in Caudal-mediated upregulation among all the different corepromoters Dr. Juven-Gershon tested. C. To test your hypothesis from Question 3B, you plan perform the same method of genereporter assays that Dr. Juven-Gershon has done. However, you will need to do somemutations to alter the core promoters. Make diagrams or clearly describe all the variouscore promoters mutants you wish to test. These include your controls, as well as any…arrow_forwardIn a female human cell, what would be the effect on X inactivation if SİRNAS that eliminate the products of the Tsix gene are added? Select one: a. One of the two X chromosomes would become inactivated. b. Both of the X chromosomes would become inactivated. c. Neither of the X chromosomes would become inactivated. d. Only the maternal X chromosome would become inactivated. e. Only the paternal X chromosome would become inactivated.arrow_forward
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