Prolactin is a protein hormone that, among other things, enables mammals to produced milk. Prolactin is secreted from cells in the pituitary gland in response to eating, mating, ovulation, and nursing. a. Prolactin is encoded by the PRL A segment of the PRL gene and its regulatory regions are shown below. The +1 site (*) and part of the promoter (#) of PRL are indicated. What is the PRL mRNA transcribed from the PRL gene? 5'-AAGCCGACCGGATATACGACGCCATGAACATGACAGGATCGCCATGG-3' 3'-TTCGGCTGGCCTATATGCTGCGGTACTTGTACTGTCCTAGCGGTACC-5' b. What is the 5'-UTR of PRL? Lleing the mRNA you transcrib what are the first 9 mino aci rolactin that are translated?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Prolactin is a protein hormone that, among other things, enables mammals to produced milk. Prolactin is secreted from cells in the pituitary gland in response to eating, mating, ovulation,
and nursing.
a. Prolactin is encoded by the PRL A segment of the PRL gene and its regulatory regions are shown below. The +1 site (*) and part of the promoter (#) of PRL are indicated. What is the PRL
mRNA transcribed from the PRL gene?
5'-AAGCCGACCGGATATACGACGCCATGAACATGACAGGATCGCCATGG-3'
3'-TTCGGCTGGCCTATATGCTGCGGTACTTGTACTGTCCTAGCGGTACC-5'
#### *
b. What is the 5'-UTR of PRL?
c. Using the mRNA you transcribed in part a, what are the first 8 amino acids of prolactin that are translated?
cis face
trans face
MTOC
Rough ER
Golgi
complex
Cell membrane
c. In what organelle is prolactin glycosylated? What motor protein would be used to transport prolactin from the rough ER to this organelle?
d. Where does exocytosis occur? What motor protein would be used to transport prolactin from the site of its glycosylation to the site of its exocytosis?
e. If this cell was stained with an antibody specific for y (gamma) tubulin, where would we expect to see the cell stained in this immunohistochemistry experiment?
Transcribed Image Text:Prolactin is a protein hormone that, among other things, enables mammals to produced milk. Prolactin is secreted from cells in the pituitary gland in response to eating, mating, ovulation, and nursing. a. Prolactin is encoded by the PRL A segment of the PRL gene and its regulatory regions are shown below. The +1 site (*) and part of the promoter (#) of PRL are indicated. What is the PRL mRNA transcribed from the PRL gene? 5'-AAGCCGACCGGATATACGACGCCATGAACATGACAGGATCGCCATGG-3' 3'-TTCGGCTGGCCTATATGCTGCGGTACTTGTACTGTCCTAGCGGTACC-5' #### * b. What is the 5'-UTR of PRL? c. Using the mRNA you transcribed in part a, what are the first 8 amino acids of prolactin that are translated? cis face trans face MTOC Rough ER Golgi complex Cell membrane c. In what organelle is prolactin glycosylated? What motor protein would be used to transport prolactin from the rough ER to this organelle? d. Where does exocytosis occur? What motor protein would be used to transport prolactin from the site of its glycosylation to the site of its exocytosis? e. If this cell was stained with an antibody specific for y (gamma) tubulin, where would we expect to see the cell stained in this immunohistochemistry experiment?
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