Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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**Instructions for Completing the Synthesis Reaction Pathway**

This exercise involves completing a multi-step organic synthesis using the provided reagents and conditions. Follow the given steps to understand the transformation process from the starting materials to the final product.

### Reaction Pathway:

1. **Step 1**: 
   - **Initial Reaction**: Convert cyclohexene to a bromo-cyclohexane using a reagent. 
   - **Reagent Options**: Consider using either bromination in light or a solvent-assisted bromination.

2. **Step 2**:
   - **Organometallic Reaction**: Form an organocuprate with a given allylic bromide. This step involves a coupling reaction with organocuprate, which combines two fragments into a larger molecule. 
   - **Reagent Options**: Look for reagents that facilitate organocuprate formation and coupling.

3. **Step 3**:
   - **Final Cyclization**: Transform the compound with double bonds into a fused bicyclic structure. This step may involve a cyclization process to form the final bicyclic product.
   - **Reagent Options**: Consider reagents that promote ring closure or cyclization.

### Possible Reagents (Select as needed for each step):

- **A**: \( \text{Br}_2, \, \text{hv} \)
- **B**: \( \text{Br}_2, \, \text{DCM} \)
- **C**: \( \text{HBr, \, DCM} \)
- **D**: \( \text{HBr, \, H}_2\text{O} \)
- **E**: \( \text{HBr, \, H}_2\text{O}_2 \)
- **F**: \( \text{NBS} \)
- **G**: \( \text{H}_2, \, \text{Pd} \)
- **H**: \( \text{LDA} \)
- **I**: \( \text{KMnO}_4 \)
- **J**: \( 1. \, \text{Li}, \, 2. \, \text{CuI} \)
- **K**: Heat
- **L**: Grubbs’ Catalyst
- **M**: \( \text{CH}_2
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Transcribed Image Text:**Instructions for Completing the Synthesis Reaction Pathway** This exercise involves completing a multi-step organic synthesis using the provided reagents and conditions. Follow the given steps to understand the transformation process from the starting materials to the final product. ### Reaction Pathway: 1. **Step 1**: - **Initial Reaction**: Convert cyclohexene to a bromo-cyclohexane using a reagent. - **Reagent Options**: Consider using either bromination in light or a solvent-assisted bromination. 2. **Step 2**: - **Organometallic Reaction**: Form an organocuprate with a given allylic bromide. This step involves a coupling reaction with organocuprate, which combines two fragments into a larger molecule. - **Reagent Options**: Look for reagents that facilitate organocuprate formation and coupling. 3. **Step 3**: - **Final Cyclization**: Transform the compound with double bonds into a fused bicyclic structure. This step may involve a cyclization process to form the final bicyclic product. - **Reagent Options**: Consider reagents that promote ring closure or cyclization. ### Possible Reagents (Select as needed for each step): - **A**: \( \text{Br}_2, \, \text{hv} \) - **B**: \( \text{Br}_2, \, \text{DCM} \) - **C**: \( \text{HBr, \, DCM} \) - **D**: \( \text{HBr, \, H}_2\text{O} \) - **E**: \( \text{HBr, \, H}_2\text{O}_2 \) - **F**: \( \text{NBS} \) - **G**: \( \text{H}_2, \, \text{Pd} \) - **H**: \( \text{LDA} \) - **I**: \( \text{KMnO}_4 \) - **J**: \( 1. \, \text{Li}, \, 2. \, \text{CuI} \) - **K**: Heat - **L**: Grubbs’ Catalyst - **M**: \( \text{CH}_2
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