Platelet-derived growth factor (PDGF) is, as its name suggests, stored in and secreted by platelets. Platelets release PDGF in the vicinity of wounds as part of their participation in the clotting response. PDGF, in turn, stimulates the proliferation of nearby fibroblasts, which help in the wound healing process. When, however, the PDGF gene is mutated or inappropriately expressed, it can lead to cancer. Why, then, does the wound healing response not lead to similar uncontrolled cell division?

Platelet-derived growth factor (PDGF) is, as its name suggests, stored in and secreted by platelets. Platelets release PDGF in the vicinity of wounds as part of their participation in the clotting response. PDGF, in turn, stimulates the proliferation of nearby fibroblasts, which help in the wound healing process. When, however, the PDGF gene is mutated or inappropriately expressed, it can lead to cancer. Why, then, does the wound healing response not lead to similar uncontrolled cell division?

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 1RQ

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