Order the sequence of Canonical signaling via Frizzled receptors. i) β-catenin can now promote proliferation and stem cell state ii) Frizzled receptor signals for dishevelled and axin binding to itself iii) LRP assisted with Wnt binding to frizzled receptor iv) Preventing the activation of GSK-β which signals for phosphorylation A. iii ->ii-> iv-> i B. iv-> iii -> ii-> i C. i-> ii-> iv-> iii

Beta-blockers are used to treat cardiovascular disorders because they are antagonists at beta-adrenergic receptors. Within the cell this activity will be seen as? OA) Increased signaling via the G₁ protein B) Increased protein kinase A activity Decreased phospholipase C activity D) Decreased cAMP levels E) Increased inositol 1,4,5-trisphosphate levels

A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and... A. produce a cellular response by altering the Na+/K+ pump located near the receptor site. B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response. C.  induce a change in the receptor molecule shape, which will ultimately produce a cellular response. D.  induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).

xytocin stimulates contraction of smooth muscles in the breast and uterine wall. The key step in muscle contraction is release of calcium from internal cell stores. With which type of receptor does oxytocin interact to cause muscle contraction?   A. Gαi-coupled receptor   B. Tyrosine kinase coupled receptor   C. Cytokine type 1 receptor   D. Ser/Thr kinase receptor   E. Gαq-coupled receptor

Which of the following statements is true?   Question 2 options:   a)  All cells will respond to the hormonal signal because hormones are broadcast throughout the body.   b)  The regulation of inflammatory responses at the site of an infection is an example of paracrine signaling.   c)  Paracrine signaling involves the secretion of stimuli into the bloodstream for distribution throughout the organism.   d)  The axons of neurons typically signal target cells using membrane-bound signaling molecules that act on receptors in the target cells.

Differential effects of epinephrine and norepinephrine among cell types and across cell types is dependent on: (Select all that apply) a.) Capillary density b.) Nuclear receptors c.) Type of G-protein expressed d.) Receptor subtype expression

1) the Ga subunit has a mutation resulting in increased GTPase activity? Why is the GPCR referred to as a GEF? What would occur in G protein signalling if

Nerve growth factor binds to which type of receptor? a.) Receptor tyrosine phosphatases b.) Receptor Serine/Threonine Kinase c.) Receptor guanylyl cyclase d.) Receptor tyrosine kinase

An extracellular signaling molecule binds to cell surface receptor. This cell surface receptor changes shape and activates a trimeric G-protein.  What kind of receptor is this? a) Ion-channel coupled receptor b) Receptor Tyrosine Kinase c) G-Protein coupled receptor d) All of the other answers are correct e) Enzyme-coupled receptor

Which of the following would inhibit the activity of TGF-Beta receptor? multiple answers    A. Deletion of Extracellular domain   B. Tyrosine Kinase Inhibitor   C. Mutation that prevents homodimerization of Type II Receptor   D. Mutation of phosphorylation site on Type I receptor   E. Inhibition Type II receptor binding to Type I receptor