Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in

Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 13RQ: A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to...

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EGF signals by binding to cell surface EGF receptors. Which of these observations, if true, would BEST explain EGF’s mechanism of action? A. EGF is hydrophilic and can easily diffuse through the cell membrane B. EGF is hydrophobic and can easily diffuse through the cell membrane C. EGF is hydrophilic and cannot diffuse through the cell membrane D. EGF is hydrophobic and cannot diffuse through the cell membrane
Which of the following statements are correct about cell signaling and proliferation in normal cells? more than one answer A. Cells require growth factors from other cells to proliferate B. Growth Factors must enter cell to signal cell growth C. Growth Factor Receptors can be oncogenes D. Protein Growth Factors can be Oncogenes E. Staurosporine is a potent inhibitor of Ser/Thr kinases and would be expected to inhibit Epidermal Growth Factor Receptor signaling
Which of the following are charcteristics you would expect of a circulating tumor cell that has undergone Epithelial-Mesenchymal Transition (select all that apply)? A. Increased N-cahedrin expression B. Increased resistance to apoptosis C. Loss of ability to secrete fibronectin D. High cytokeratin expression E. Elevated PDGF Receptor Expression
which of hthe following would result in a persisting proliferation response to growth factor receptor activation after the ligand is no longer binding to its rceptor kinase? 1. Both a mutation that blocks the GTPas activity of Ras and a mutation that blocks the exchange of GDP with GTP would cause the response to persist. 2. a mutation that blocks the GTPas activity of Ras 3. neither a mutation that blocks the GTPas activity of Ras nor a mutation that blocks the exchange of GDP with GTP would cause the response to persist 4. a mutatiaon that blocks the exchange of GDP with GTP
Epidermal growth factor (EGF) signals through a receptor, tyrosine kinase. EGF signaling promotes cell division by increasing nuclear concentrations of CyclinD through both the MEK and AKT signaling pathways as shown in the diagram. Use the EGF Pathway passage to answer the questions. EGF signals by binding to cell surface EGF receptors. Which of these observations, if true, would BEST explain EGF’s mechanism of action? A. EGF is hydrophilic and can easily diffuse through the cell membrane. B. EGF is hydrophobic and can easily diffuse through the cell membrane. C. EGF is hydrophilic and cannot diffuse through the cell membrane. D. EGF is hydrophobic and cannot diffuse through the cell membrane. Which of these BEST describes how the signal is transduced from the EGF receptor to the Ras protein? A. Ras is phosphorylated. B. Ras is dephosphorylated. C. Ras binds to a GTP molecule. D. Ras hydrolyzes a GTP molecule. High concentrations of nuclear CyclinD is required for entry into S…
Which of the following exert their cell signaling ability proteteolysis of other proteins? multiple answers A. RAS B. Epidermal Growth factor C. Notch Receptor D. TGF-Beta Receptor E. Estrogen Receptor
In the RAD signaling pathway the EGF ligand binds the EGF receptor, this initiated a phosphorylation cascade that results in cell proliferation. Which of the following statements is correct: a. RAS protein is the sognal b. EGF ligand is the signal c. cell proliferation is the signal d. EGF receptor is the signal e. none of the above
A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct? a. EGF signaling cascades would be active for longer in the cell. b. EGF signaling cascades would be active for a shorter period of time in the cell. c. EGF signaling cascades would not occur. d. EGF signaling would be unaffected.
State whether the level of each of the following protein in a cancer cell is higher or lower than normal and how is that beneficial to the cancer cell? a. ARF protein b. MDM2 c. caspases d. Fas receptor e. TNF-α (new answer & typed please)
State whether the level of each of the following protein in a cancer cell is higher or lower than normal and how is that beneficial to the cancer cell? a. ARF protein b. MDM2 c. caspases d. Fas receptor e. TNF-α
Which of the following statements are correct about cytoplasmic signaling in cancer cells? Multiple answers. A. Only minor modifications of cell control machinery are required for normal cells to become highly proliferating cancer cells B. Immediate early genes are induced in the presence of protein synthesis inhibitors C. Many immediate -early genes are oncogenes D. Delayed early genes are highly expressed in the presence of protein synthesis inhibitors E. Delayed early genes are highly expressed in normal cells in the absence of growth factors
Glucocorticoids are sterojd hormones that are released into the circulation and will cause changes to gene expression in the cells that respond. Which of the following would be a factor that can determine whether a cell will respond to circulating glucocorticoids? Whether the cell expresses the lac repressor. O A. O B. Whether the cell expresses the CREB protein. Whether the cell expresses the glucocorticoid receptor. C. Whether CAMP is produced at high levels by adenylyl cyclase. D. O E. Whether adenylyl cyclase is activated or not.

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	A.	Mutation of active site residue responsible for tyrosine phosphorylation.
	B.	Deletion of extracellular ectodomain
	C.	Mutation in ectodomain that prevents binding of EGF
	D.	Cell expresses EGF
	E.	Mutation in promoter that increases expression of EGF receptor
	F.	Dimerization of receptor without growth factor
	G.	Mutation in EGFR promoter that decreases expression of receptor