mutations in breast cancer susceptibility genes BRCA1 & 2 principally cause with ? (a) nucleotide excision repair (b) translational fidelity (c) transcriptional fidelity (d) regulation of meiotic recombination at the Holiday Junction (e) Double Strand Break repair

Briefly describe the molecular processes that cause one X chromosome in each female cell to be active and the other X chromosome to be inactivated.

Explain about how X chromosome inactivation takes place in mammals at the chromosomal and molecular level.    B. What genes are involved in inactivating a human X chromosome?  . C. What role does  X chromosome-specific inactivating transcript --XIST-- non coding RNA play in the inactivation of the human X chromosome.

In 2013 the actress Angelina Jolie elected to have prophylactic double-mastectomy surgery to prevent breast cancer based on a positive test for mutation of the BRCA1 gene. What are some potential positive and negative consequences of this high-profile example of acting on the results of a genetic test?

19: What are 3 phenotypes of GA, or BR, or ABA, or CK over-producing mutants.   20: Think about a hormone receptor, specifically the structure of the receptor. Describe ONE why a mutation would cause insensitivity to the hormone, AND ONE way it could cause hypersensitivity to the hormone. Explain your answer to each.   22: Not all cells in tissues are the same. They differentiate from stem cells. Describe how ONE cell type acquires cell identity. (Pick any cell in the plant)

In a female human cell, what would be the effect on X inactivation if SİRNAS that eliminate the products of the Tsix gene are added? Select one: a. One of the two X chromosomes would become inactivated. b. Both of the X chromosomes would become inactivated. c. Neither of the X chromosomes would become inactivated. d. Only the maternal X chromosome would become inactivated. e. Only the paternal X chromosome would become inactivated.

The idea that sperm carry more mutations thanoocytes makes sense. Explain how?

Q. Both histone deacetylase (HDAC) and Xist would be on a list of genes involved in X chromosome inactivation. In which of the following ways would the histone deacetylase gene be similar to the Xist gene?   A. They would both be transcribed. B. They would both be translated. C. They would both undergo intron splicing. D. They would both be transported to the cytoplasm after transcription.