Mrem is a value that indicates the amount of radiation damage incurred. Radiation dose should be multiplied by a factor that measures the relative damage. This multiplication factor is known as the relative biological effectiveness (RBE). The product of the radiation dose in rad and the RBE of the radiation give the effective dosage in rem (roentgen equivalent for man): number of rem = (number of rad) (RBE). The value of mrad found in Part C is multiplied by the RBE, 9.5, to determine mrem.
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- Iodine-131 is commonly used for the treatment of Graves' disease, which is a disease of the thyroid gland. The number of 131I used depends on the size of the patient's thyroid gland. If the dosage for 131I is 86 microcuries per gram of the thyroid gland, and assuming all the iodine given will accumulate in the thyroid gland, then: a. What activity dose of 131I should be given to a patient who has a thyroid gland weighing 15 grams?b. What is the value of the decay rate constant I-131 if the half-life = 8.07 days?c. How many grams of 131I to give?d. How many grams of 131I are left in the patient after 1 month?You own a compounding able pharmacy and are presented with a presciption for fortified gentamicin eye drops 5mg/mL. You have in stock a gentamicin injection at 40mg/ml and 5ml gentamicin eye drop labled to contain 3mg/ml. How many mililiters of the injection should be added to the 5ml of the commercial eye drop to gice it a 5mg/ml "fortifited" concentration?A stock solution of drug Y is available at 10%w/v. You need to dilute this with Syrup, BP in order to supply a patient with a solution containing 5mg/mL of drug Y. Assuming no volume displacement effects, what is your formula for the preparation of 100 mL of the final solution?
- Digitalis, a drug used to control atrial fibrillation in patients is to be delivered to have a the drug amount to 20.0 μμg/kg body weight (2.205 pounds = 1.00 kg). The drug concentration must be carefully controlled and accurately measured or the patient may die from too low of concentration from heart complications or too high concentrations of fatal overdose. Calculate the mL of digitalis needed to treat a 160.0 pound patient using 0.800 mg/mL digitalis solution.The amount of dimercaprol administered to a 75-kg patient for mercury poisoning when the following dosage regimen is prescribed: 3 mg/kg every 4 h over 2 days, three times a day on the third day, then twice daily for 10 * .days 0.75 g O 0.787 g O 0.882 g O 7.55 g O 7.875 g OYour 64YO 152lb, 5ft 8in female patient daignosed with advanced bladder cancerhas been prescribed ifosamide 1500mg/m2/day IV for 5 days. You calculate the BSA using the Mosteller method as being 1.82m2. Ifosfamide is available in 60mL vials containing 3g of drugs. How many mL will you administer each day?
- A patient’s treatment plan requires two IV solutions to be administered:20% magnesium sulfate, MgSO4, and 10% calcium chloride, CaCl2. Thenurse is concerned, MgSO4 and CaCl2 are listed as incompatible IVsolutions with the risk of solid precipitate formation (image shown toright). Write the chemical equation that predicts the products thatform when combining MgSO4 and CaCl2. Please use the providedsolubility chart to help you determine chemical phases.A mixture containing only KCl and NaBr is analyzed by the Mohr Method. A 0.3172-g sample is dissolved in 50 mL water and titrated to the Ag2CrO4 endpoint, requiring 36.85 mL of 0.1120 M AgNO3. A blank titration requires 0.71 mL of titrant to reach the same endpoint. Report the % (w/w) KCl and NaBr in the sample. [Ans . 84.41 % (w /w); 17.59 % (w /w)]sodium nitrite (NaNO2) is used by emergency medical personnel as an antidote for cyanide poisoning (for this purpose, it must be administered immediately). Based on the discussion of cyanide poisoning, suggest a mechanism for the life-saving effect of sodium nitrite.
- Calculate the standard reduction of 3-phosphoglycerate using val ues from your book, and compare the reduction potential to others tabulated in the book.Find the approximate radiation dose (in mSv) for 0.1 Gy exposure to thermal neutrons. (Hint: relative biological effectiveness for various types of radiation can be found in Table 32.2 in the text.) A range of answers is acceptable.Paclitaxel is used to treat ovarian cancer by infusion at a concentration of 0.6 mg/mL over 24 hours. A dose of 135 mg/m² has been prescribed for Sero. Sero is 1.06 m tall and weighs 92 kg. Paclitaxel comes in vials of 150 mg/25 mL. Calculate the volume of 5%w/v glucose solution that would be required to dilute the concentrated solution to prepare an paclitaxel solution of the required strength.