Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Whatis the main idea behind the conformational coupling mechanism for ATP synthase? Describe the three conformational states.
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- How can ATP hydrolysis be used to drive an endergonic reaction via reaction coupling?arrow_forwardHis388 Glu357 His388 Glu357 Ring opening Proton HO HO abstraction HO но- G6P He NH- NH His388 His388 His388 Glu357 Glu357 Glu357 HO но HO но- но OH cis-enediol F6P Ring closure intermediate OH Describe the mechanism shown above for phosphoglucose isomerase. Describe the chemistry of each step • How the enzyme appears or might facilitate the chemistry How the enzyme increases the reaction rate.arrow_forwardS 1 CH₂ ✪ NH3 0=0 H₂C HN 6 NH CH₂ 'S Co A L CH₂ NH 4. Describe the role of His in the catalytic mechanism shown.arrow_forward
- I don't understand it. Can u help me? Can u help me to explain this to me, pleasearrow_forwardWhat are the three key mechanisms and their associated features that are utilized by enzymes to catalyze reactions. Additionally, which two mechanims of the three you listed does the enzyme chymotrypsin use?arrow_forwardNH3 H-SCO A LES NH CH₂ NH CH₂ CH₂ 3 H-SCO A H3C SCO A 5. Describe the role of His in the catalytic mechanism shown.arrow_forward
- 1. Provide the best coenzyme(s) for each step shown below. Give a 1–2 sentence rationale for your choice. 2. Reaction (C) can require multiple coenzymes, or the enzyme may only require one. Briefly describe how the reaction that uses only one coenzyme works. Be specific about the mechanism.arrow_forwardFocusing on the mechanism linking complex I and ATP synthase depicted in figure 3 in the article, compare that hypothetical mechanism to the classical presentation described in textbooks. What are the major differences between this mechanism and Peter Mitchel’s original chemiosmotic theory? What are the similarities.arrow_forwardV-class proton pumps run backward relative to the F-class ATP synthase. Consider the cartoon, which shows the conformations of the beta-subunits and ATPIADP + Pj of the F-class synthase. Which of the following associations between the conformation of the beta subunit and ATP/ADP + P¡ is correct for V- Binding Change Mechanism loose binding ADP+P ATP ATP class pumps? C repeat ADP + P, ADP АТР tight binding АТР +P оpen АТР O The open conformation releases ATP. Hydrolysis of ATP to ADP + P¡ drives the change from tight to loose. O Binding of ADP + P¡ drives change from open to loose. Hydrolysis of ATP to ADP + Pj drives the change from open to loose.arrow_forward
- Activity of the light reactions (ETC) can be assayed using an artificial, reducible compound (e- acceptor) added to take the place of the terminal electron acceptor. The artificial e- acceptor used is called DCPIP, a blue dye that turns colorless when it accepts electrons. The reaction is: H2O + DCPIPoxidized (blue) --> O2 + DCPIPreduced (colorless) What molecule from the light reactions of photosynthesis does DCPIP compete with? NADPH H2O ATP ADP NADP+arrow_forwardb) Why might the compound shown below act as a transition state analog of phosphoglucose isomerase? A drawing of the normal transition state for this enzyme is needed. HO- OH T .N -OH -OH CH₂OPO₂²-arrow_forwardCould you help propose a reasonable mechanism for the following biochemical transformation?arrow_forward
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