Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- Sonicating a suspension of mitochondria produces submitochondrial particles derived from the innermitochondrial membrane. These membranous vesicles seal inside out, so that the intermembrane space of themitochondria becomes the lumen of the submitochondrial particle. Explain (or diagram) the process of electrontransfer and oxidative phosphorylation in these particles. Assuming all the substrates for oxidativephosphorylation are present in excess, does ATP synthesis increase or decrease with an increase in the pH ofthe fluid in which the submitochondrial particles are suspended? Why?arrow_forwardIn hepatocytes, the enzyme glucokinase catalyzes the ATP-coupled phosphorylation of glucose. Glucokinase binds both ATP and glucose, forming a glucose-ATP-enzyme complex. The enzyme then transfers the phosphoryl group directly from ATP to glucose. Select the advantages of phosphoryl group transfer compared to hydrolysis and subsequent phosphorylation? ATP hydrolysis is thermodynamically unfavorable compared to group transfer. Glucokinase increases the transition state energy, favoring glucose phosphorylation. The process takes advantage of the high phosphoryl group transfer potential of ATP. Reaction intermediates do not need to be present in excess. Incorrectarrow_forwardSeveral general characteristics of metabolic reactions or reaction pathways are listed. Classify them into the appropriate metabolic category. utilize ATP Anabolism convert NAD+ to NADH convert small compounds to larger compounds Answer Bank convert NADPH to NADP+ generally exergonic (spontaneous) Catabolism convert large compounds to smaller compoundsarrow_forward
- During glycogen synthesis, glucose-1P is converted into a molecule called UDPG. This reaction also cleaves uridine triphosphate (UTP) forming uridine monophosphate and pyrophosphate (PPi). Provide four reasons why UTP can be used to power this reaction (no diagrams necessary).arrow_forwardWhich of the following statements about the Krebs Cycle is true? There may be more than one answer. Select any and all that apply. It is a linear 10 step pathway It generates ATP molecules directly through oxidative phosphorylation It produces two molecules of carbon dioxide It begins with acetyl coenzyme A and oxaloacetate combining It converts glucose to carbon dioxide It is a point of entry for the products of amino acid catabolism to be converted into energy It is an anaerobic process that produces molecules for an aerobic process that comes later The first step is the breakdown of glucose into glyceraldehyde-3-phosphatearrow_forwardHow much fat (in grams) would the body have to burn to produce the daily minimum requirement of 40 kg ATP from ADP and phosphate? Assume that: 1. The fat is metabolized completely to water and carbon dioxide. 2. The energy that is released can be used entirely for ATP production. 3. Complete oxidation of 1 g of fat to water and CO2 releases 9 kcal or 37 kJ. 4. The Delta G for ATP hydrolysis is -30.5 kJ/mol. You will have to look up one more value online to answer this question, but you do not need to know anything about lipid metabolism. A) approx. 16 to 17 g of fat B) approx. 65 to 66 g of fat C) approx 22 to 23 kg of fat D) approx. 267 to 268 g of fat E) approx. 5 to 6 kg of fatarrow_forward
- ATP synthase, hexokinase, and isocitrate dehydrogenase are important enzymes in aerobic respiration. Please provide a description for each enzyme containing the following information: (1) the metabolic stage in aerobic respiration they are involved in, (2) the enzyme class where they belong, and (3) the chemical eaction they catalyze.arrow_forwardStarting with glucose, there are five steps in the EMP/TCA metabolic pathways that produce NADH (which is converted to ATP or energy). Use class notes, Shuler, Kargi and DeLisa book, or the internet. 1. A. Draw the chemical structures of the reactant(s) and product(s); as well as a balanced chemical reaction for the step in the TCA (Krebs) cycle where isocitrate is converted to a-ketoglutarate (step 3 in the class notes). (You don't need to draw the structures of coenzyme A (COA), NAD* or NADH.) B. What enzymes catalyze steps 3 and 5 in the Kreb's cycle from the class notes? C. Would you categorize step 8 in the TCA cycle where malate is converted to oxaloacetate as an oxidation or reduction of malate? D. Considering that some energy is spent transporting acetyl-CoA to mitochondria, how much net energy (in kcal) is produced by converting 15 mol of glucose to CO₂ in the glycolysis & Krebs cycle pathways? E. How many kcals of energy from oxidizing 15 mol of glucose to CO₂ (your answer to…arrow_forwardThe metabolic pathway responsible for clearing lactic acid from our bodies is called the Cori Cycle. It occurs in the liver, and converts lactic acid back into pyruvic acid, and then into glucose. The glucose can then be used for energy metabolism again. However, the Cori Cycle requires a net input of 4 ATP to operate. Based on this information how can you describe the Cori Cycle? [Select any/all that apply.] Cori Cycle is exergonic. Cori Cycle is anabolc. Cori Cycle is catabolic. Cori Cycle is endergonic.arrow_forward
- Indicate at what step in the glycolysis pathway each of the following events occur 1. First phosphorylation of ADP occurs 2. First “energy rich” compound is produced 3. Second “energy rich” compound undergoes reaction 4. First isomerization reaction occurs 5. Second formation of ATP occurs 6. Second “energy rich” compound is produced 7. ATP is converted to ADP for the second time 8. A dehydration reaction occursarrow_forwardHow many ATP are produced by a single 10 carbon-long fatty acid? Consider: where beta-hydrolysis occurs & how many NADH & FADH2 are made Assume: each NADH produces 2.5 ATP, each FADH2 produces 1.5 ATP Show your workarrow_forwardThe coenzymes NAD+ and NADP+ are important electron carriers that pick up electrons from one pathway and deliver them to another. Below is a list of pathways or enzyme complexes that we have covered in class. Indicate which coenzyme these pathways or complexes produce by writing NAD+, NADP+, NADH or NADPH in the blank provided. ________ glycolysis ________ citric acid cycle ________ alcoholic fermentation ________ pyruvate dehydrogenase complex ________ gluconeogenesis ________ mitochondrial electron transport ________ photosynthesis light reactions ________ photosynthesis dark reactionsarrow_forward
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