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- Select one: and p53 is a a transcription factor, motor protein b. kinase, motor protein c. transcription factor, kinase d. motor protein, transcription factor e. motor protein, protease f. kinase, transcription factorThe Bax protein _____, thus _____ apoptosis. Select one: a. none of the above b. promotes caspase activity, increasing c. inhibits caspase activity, decreasing d. promotes caspase activity, decreasing e. inhibits caspase activity, increasing Clear my choiceLigand-activated receptors should be ________ before they can bind DNA and activate transcription. a. dephosphorylated b. phosphorylated c. bound by their metabolite ligand d. bound by their hormone ligand
- After it has been activated a G-protein _______. moves along the inside of the cell's membrane and activates enzymes binds to its receptor in the cell's nucleus and initiates translation travels in the bloodstream to its target cell and then binds to its receptor binds to a receptor on a nearby cell and then activates multiple proteinsHow cyclin makes Cyclin-dependent Kinases functional? (Refer to the diagram BELOW)A. activates Cdks as kinaseB. attach phosphate group to specific target proteinC. directs the Cdk to a specific set of target proteinsD. A and C are correctWhich of the following would move the farthest on a protein gel? A. cyclin dependent kinase (34 kDa) B. insulin receptor (156 kDa) C. phosphofructokinase (85 kDa) D. sodium-potassium pump (100 kDa)
- Which of the following elements may be in the transduction part of cell signaling? Select one: a. A phosphatase b. A kinase c. cyclin AMP d. ions e. All answers are correctThe diagram describes a signaling pathway involved Protein Kinase A (PKA). Activated PKA phosphorylates a gene regulatory protein called CREB that then activates transcription of some target genes. adrenaline activated GPCR [Select] activated, a subunit of G protein (G) CYTOSOL NUCLEUS [ Select] active PKA phosphorylated by PKA [Select] hydrolyze GTP GTP activated adenylyl cyclase inactive PKA DNA ATP activated, phosphorylated gene regulatory protein RNA cyclic AMP | Select] PKA from binding to its nuclear import receptor Which situation (s) described below would lead to an increase in the transcription of these target genes? Mark yes or no for each of the following choices. active PKA C nuclear pore activated target gene TRANSCRIPTION a mutation in the CREB gene that produces a protein that cannot be a mutation in the nuclear import sequence of PKA that prevents the enzyme unable to interact with the a subunit of the G protein ✓a mutation in the a unit of the G-protein that makes G,…A mutation where Protein kinase A and Ca2+/calmodulin kinase 2 is inhibited a. Increased Cytosolic Calcium b. Decreased Cytosolic Calcium c. No change in Cytosolic Calcium d. Slow progressive decrease in cytosolic calcium
- The diagram introduces the pathway through which nitric oxide (NO) triggers smooth muscle relaxation in a blood-vessel wall and leads to increase in blood flow. It also contains information on how the drug nitroglycerine functions to relieve angina. (A) smooth muscle cell (B) lumen of blood vessel acetylcholine arginine- basal lamina endothelial cell NO endothelial cell Figure 15-40 Molecular Biology of the Cell 6 (Garland Science 2015) [Select] activated NO synthase (NOS) [Select] RAPID DIFFUSION OF NO ACROSS MEMBRANES [Select] that it cannot produce cGMP [Select] The drug nitroglycerine is directly converted to NO and triggers relaxation of the coronary blood vessels to relieve angina (chest pain or discomfort that occurs if an area of the heart muscle doesn't get enough oxygen-rich blood), usually a symptom of coronary heart disease NO bound to guanylyl cyclase GTP Which of the following situations would lead to relaxation of the smooth muscle cells in the absence of acetylcholine?…Src/LcK is a cancer-associated kinase. a. Name the domains that constitute this protein and give the function of each one. b. Define a domain and state the difference between domain and motifMatch the terms with the most suitable description. ___ operon a. makes a man out of you ___ Circadian rhythm b. binding site for repressor ___ Barr body c. can be epigenetic ___ differentiation d. inactivated X chromosome ___ mRNA zip code e. controls multiple genes ___ DNA methylation f. localization mechanism ___ eyeless g. speeds transcription ___ activator h. required for eye formation ___ SRY gene i. effect of regulatory loops ___ operator j. cells become specialized
