In your earlier research for this case study, you have discovered that nucleotides 1591-1593 (in the cDNA sequence, not CDS) are deleted in many CF patients causing a ΔPhe508 mutation in the CFTR protein. What are these three nucleotides in the CFTR cDNA sequence? Hint: you can copy the cDNA sequence from NCBI (with numbers) into a word processing program (e.g. Microsoft Word) to study the sequence or use a free DNA software program available by searching the internet.
In your earlier research for this case study, you have discovered that nucleotides 1591-1593 (in the cDNA sequence, not CDS) are deleted in many CF patients causing a ΔPhe508 mutation in the CFTR protein. What are these three nucleotides in the CFTR cDNA sequence? Hint: you can copy the cDNA sequence from NCBI (with numbers) into a word processing program (e.g. Microsoft Word) to study the sequence or use a free DNA software program available by searching the internet.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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In your earlier research for this case study, you have discovered that nucleotides 1591-1593 (in the cDNA sequence, not CDS) are deleted in many CF patients causing a ΔPhe508 mutation in the CFTR protein. What are these three nucleotides in the CFTR cDNA sequence? Hint: you can copy the cDNA sequence from NCBI (with numbers) into a word processing program (e.g. Microsoft Word) to study the sequence or use a free DNA software program available by searching the internet.
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