Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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DNA replication can proceed only in the 5’ to 3’ direction
replication on the leading strand is slower than replication on the lagging strand
DNA polymerase tends to slip while replicating the lagging strand
DNA polymerase has to alternate between the leading and lagging strands during replication
none of these are true.
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- E. coli replication on the lagging strand is carried out by DNA polymerase I is initially synthesized as Okazaki fragments is synthesized continuously has this DNA strand synthesized in a 3' 5' directionarrow_forwardIf a mutation occurred that prevented single stranded binding proteins from binding, the result would be: O Replication would not be initiated O DNA would be synthesized on the leading strand, but not the lagging strand Replicating would be initiated, DNA would unwind, RNA primers would be laid down, but DNA polymerase would not bind O The newly synthesized RNA would not be able to leave the DNA template Replication would be initiated, but RNA primers would not anneal to the DNAarrow_forwardOptimal DNA replication requires the coordinated effort of all the following EXCEPT: gyrase single strand binding proteins DNA polymerase II Primasearrow_forward
- In comparing prokaryotic and eukaryotic replication, pick the one that in INCORRECT. Both have semiconservative replication Both strands made at same time by replisome consisting of helicase plus DNA pol holoenzyme Eukaryotes and prokaryotes both have leading and lagging strands RNA is only needed to initiate DNA synthesis in prokaryotesarrow_forwardAs the strands are synthesized in replication, which of the following is true? the leading strand is synthesized continuously from the 5' to 3' direction while the other strand is synthesized discontinuously in the 3' to 5' direction both strands are synthesized in the 5' to 3' direction the strand that shows the Okazaki fragments is synthesized in the 3'-5' direction. both strands are synthesized continuouslyarrow_forwardWhich statement is true about dna replicationarrow_forward
- Semi-discontinuous replication means that: DNA synthesis only occurs in the same direction as the replication fork. the double helix unwinds and each strand serves as a template for a new DNA molecule. there are Okazaki fragments associated with the leading strand. DNA synthesis occurs in both a 5’ to 3’ and a 3’ to 5’ direction. there is both a leading and a lagging strand associated with each replication fork.arrow_forwardGiven the replication events listed below which even takes place first Single Strand binding proteins bind Primase adds an RNA primer Helicase unwinds the DNA double helix DNA polymerase begins adding DNA nucleotidesarrow_forwardWhy do we find multiple, short RNA pieces inserted into the lagging DNA strand during DNA replication? Question 43 options: the DNA polymerase is replaced by the RNA polymerase in these regions for unknown reasons the DNA polymerase doesn't copy flawless and adds sometime uracil instead of thymine to the growing daughter nucleotide strand multiple RNA primers have been added with the help of the primase enzyme to create multiple start sites for the DNA polymerase Retroviruses sometimes like to insert their RNA into the replication fork and favor the lagging strand multiple RNA pieces are most likely found in the leading not the lagging strand during DNA replicationarrow_forward
- 1) Fill in the following replication bubble. Be sure to draw and label the origin of replication (both sides), the leading and lagging strands, & the 5' and 3' ends of alI DNA fragments. 5' 3'arrow_forwardReplication in eukaryotes begins at the OriC sequence. This particular sequence is characterized by (select the correct statements): A-T rich and therefore energetically more favourable to localy unwind DNA. Contains the DnaA boxes. Recruits histone acetyltransferases. Is locally unwound by DnaA, HU and IHF proteins. QUESTION 16 The Single Strand-binding proteins (SSBS) in prokaryotes and the Replication Protein A (RPA) in eukaryotes are functionally equivalent. Their role in the DNA replication process is to (select the correct statement): Stabilize the single stranded DNA structure after unwinding by the DNA helicase. Recruit the general transcription factors to the promoter. Relieve the torsional stress ahead of the replication fork. Induce double strand breaks. O O O O O O Oarrow_forwardDNA replication in vivo requires a primer with a free 3' end. What molecule provides this 3' end? Group of answer choices DNA ligase DNA primer RNA primer Helicase None of these is correctarrow_forward
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