In a study of healthy volunteers, chewed aspirin has indicated a faster (5 min) effect as opposed to regular swallowed aspirin (12 minutes).  Which of the following mechanisms explains the above effect? Chewing allows for aspiring to act faster as a reversible COX-1 inhibitor. Chewing allows for faster dissolution time to reach its peak effect quicker. Chewing allows for aspiring to act faster as a reversible inhibitor for thromboxane A2.

How does ligand binding, and voltage changes regulate specific types of ion channels? Provide examples of different drugs action on such targets by giving discussing briefly their mechanism of action.

A GRK inhibitor would have what effect on GPCR inactivation in the presence of a GPCR agonist? (a) it would decrease it; (b) it would maintain the same rate of inactivation; (c) it would increase it.

Usually LTP requires repeated learning trials to occur but single trial LTP is possible. Explain. What is some of the evidence to support single trial LTP?

Estimate the concentration of norepinephrine at which the response reaches 50% (disregard that there are two curves) express the concentration in microM. List the concentrations at which the response was tested.

Consider the person Harrison Johnson, aged 21, was diagnosed with Type 1 diabetes mellitus when he was 12 years old after a viral illness. He and his family learned to manage his diabetes although his teenage years were difficult with episodes of low and high blood glucose. He is now a 3rd year nursing student and enjoys the course very much. However, at times he has found the study and PEP stressful, and this has made managing his blood glucose difficult at times. He is very active and enjoys running and football, and nights out with his friends. Harrison acquired both a continuous glucose monitor and an insulin pump 3 months ago. He is still learning how to use them effectively. Last week Harrison developed a heavy cold with a significant green mucus discharge. He has been feeling very unwell, experiencing episodes of rigors and fever. He has a productive cough. He has presented to the clinic feeling even worse, very tired, thirsty, and urinating more frequently. Collect cues Vital…

Please ASAP. Thankyou

Briefly describe the difference between agonist and antagonists. What is a difference comparing to allosteric modulators? What are major factors that alter pharmacokinetics in elderly? Give some examples.

What are the superiorities of PPI over H2 blocker? How Omeprazole acts? Please briefly explain at your own words.

richard thompson is a 35 year old male whose blood pressure was consistently tested at approximately 145/100 mmHg despite following a low-sodium diet, omitting alcohol, and beginning an exercise program. He has no symptoms related to this elevated blood pressure. He has a history of asthma. Which of the receptor antagonists might be useful for treating his hepertension without worsening his asthma?