III. Predict the correct structure the following sigmatropic rearrangement and detailed the appropriate mechanism (Your answer should include an illustration of the transition state of the reaction Take the product's stereochemistry into consideration). Ph Ph Heat

For each reaction below, provide all the expected constitutional isomer monohalogenated products. Ignore stereochemistry and do not include duplicates of the same constitutional isomers. Consider the expected selectivity (or lack of) for the chlorination and bromination reactions. Also consider possible resonance structures where appropriate a. b. Cl₂ heat NBS light

For the following reaction, a. List all expected organic and covalent products. b. For each organic product, write out a mechanism using arrow notation and any necessary transition states. Remember to include stereochemistry and E/Z if necessary or required. ONa

Compound A, C₂H₁ reacts with 1 molar equivalent(s) of hydrogen upon catalytic hydrogenation. A undergoes reaction with ozone, followed by 2n treatment, to give i O CH₂CCH₂CH₂CH₂CH₂CH₂CH₂ Propose a structure for A • You do not have to consider stereochemistry You do not have to explicitly draw Hatoms In IF ChemDoodie Previous

Draw the major product(s) to the reactions. Your answer should take into account regioisomers, if applicable.

Predict the major, organic product for the following reaction sequence without sterechemistry depicted then predict the stereochemical outcome of the reaction sequence.

For the following reaction, H+ Но a. List all expected organic and covalent products. b. For each organic product, write out a mechanism using arrow notation and any necessary or required transition states. Remember to include stereochemistry and E/Z if necessary or required.

This reaction is also an important reaction of the tricarboxylic acid cycle in cells, wherein the reaction occurs in neutral solution, so the acid groups are both ionized to the carboxylate form. The reaction is catalyzed by the stereospecific enzyme fumarase that utilizes only the trans form of 2-butenedioate ion (also known as fumarate) and produces only the (S)-2-hydroxysuccinate enantiomer (also known as (S)-malate). Draw the correct stereochemical structures of these two compounds of the fumarase-catalyzed reaction. Be sure to include all hydrogen atoms and show the carboxylates as anions.