Draw the correct stereochemical structures of these two compounds of the fumarase-catalyzed reaction. Be sure to include all hydrogen atoms and show the carboxylates as anions.

What is the product of the following reaction sequence? You can ignore and stereochemistry. The second step (10) can she be accomplided with H₂O. O x OH X 1 H₂O MgBr

b) Optical isomers can often be formed during these reactions. For products A-H indicate how many different optical isomers you expect to form for each from these reactions (you do not have to indicate whether they are diastereomers/enantiomers). c) In the preparation of substance D by ozonolysis, the second step is necessary treatment of the reaction mixture with zinc in acetic acid. If we forgot this step, we would get substance V instead of substance D, which would probably explode when isolated. What is the structure of substance V? *24 X 1: ozone V e) What products do you expect to form if they react with alkene X: I - HBr in diethyl ether; II - Brl in methanol; III - PhSCI in diethyl ether; IV - Selectfluor in methanol. P M EtOH NA EtONa PhSNa EtOH E H+ O TsCl Pyridín F- T2, Pd/C G4 mCPBA H₂SO4 10 %, H₂O 1: BH3 H◄ 2: H₂O₂ ill X Br₂ cyclohexane HCI A > В B HBr warmth, benzoylperoxid 1: ozone 2: Zn, ACOH Mg THF с D D₂O K I + J NaOH

Is sildenafil chiral? If so, which of the possible stereoisomers are formed in this synthesis?

1) A student measures 7.45 cm³ of chloroform using a glass syringe. Given that the density of chloroform is 1.48 g/mL, and the molar mass is 119.38 g/mol, how many moles of chloroform did the student measure?

Provide the missing reactants, reagents, or products for the following reaction sequences below. If a sequence leads to a racemic mixture you should indicate "+ enantiomer." [or NH₂ CH,CHÍNH, H* (catalyst) total ele 1. LIAIH4 2. H₂O 0:

4a) Using clear and informative drawings as well as few words, explain the stereochemistry of this sequence of reactions. CO₂Me 1. H₂, Pd/C 2. NaOMe 3. H+ CO₂Me

4. Draw the structure of product, substrate or condition in the following reactions (should clearly show the stereochemistry) a) HBr (2 equiv) b) 1) NaNH2 2) Ме 1) OsO4 2) NaHSO3 c) t-BUOK t-BUOH Hint: this is the only product formed