If a mutation in a sodium channel in an Intestinal epithelial cell caused a marked decrease In the concentration gradient of sodium across the plasma membrane, which of the following would you expect to observe? a decrease in Na/K ATPase activity. an increase in the movement of glucose across the basolateral membrane to the extracellular space an increase in sodium/glucose co-transport into the cell across the apical membrane a decrease in cytoplasmic glucose concentration

If a mutation in a sodium channel in an Intestinal epithelial cell caused a marked decrease In the concentration gradient of sodium across the plasma membrane, which of the following would you expect to observe? a decrease in Na/K ATPase activity. an increase in the movement of glucose across the basolateral membrane to the extracellular space an increase in sodium/glucose co-transport into the cell across the apical membrane a decrease in cytoplasmic glucose concentration

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter3: The Plasma Membrane And Membrane Potential

Section: Chapter Questions

Problem 1ACR: When William H. was helping victims after a devastating earthquake in a region not prepared to...

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Movement of glucose from one side to the other side of the intestinal epithelium is a major example of transcellular transport. How does the Na+/K+ ATPase power the process? Why are tight junctions essential for the process? Why is localization of the transporters specifically in the apicalor basolateral membrane crucial for transcellular transport? Rehydration supplements such as sport drinks include a sugar and a salt. Why are both important to rehydration?
Glucose transporters are either open to the extracellular side or open to the intracellular side of the membrane but never both at the same time. True or False? Movement of an ion against or up its concentration gradient is exergonic. True or False? If an amino acid is transported into intestinal epithelial cells through a transporter that is able to concentrate the amino acid using a sodium ion moving down its gradient, this transporter is an example of primary active transport. True or False? The maximum gradient a primary active transporter can build has a potential energy which in magnitude is greater than or equal to the magnitude of the energy released by ATP hydrolysis. True or False?
Acetylcholine is a neurotransmitter that, when bound to its receptor, causes the receptor to open a channel that allows the flow of Na+ ions into neurons. When the Na+ ions begin to flow into the neuron, this change in the net charge across the neuronal cell membrane often triggers Ca2+ ion channels to open. In this scenario, the acetylcholine receptor would be acting as a channel, and the Ca2+ channels would be classified as voltage-gated; leaky ligand gated; voltage-gated symporter; antiporter None of the above. ion
Fill in the blanks: One example of transepithelial transport is the system in intestinal epithelial cells that includes the in the intestine-facing membrane, the energy facing the blood, allowing facilitated diffusion out of the cell into the blood. requiring and the Na+/glucose cotransporter, Glut2, CFTR O Na+/glucose cotransporter, Na+/K+ ATPase, Glut2 Na+/K+ ATPase, Na+/glucose cotransporter, Glut2 Glut2, Na+/glucose cotransporter, Na+/K+ ATPase O Na+/glucose cotransporter, CFTR, Glut2
Which of the following statements best describes the absorption of glucose? Absorption of glucose requires digestion by aminopeptidases on absorptive epithelial microvilli before absorption of the carbohydrate smaller units such as glucose. Absorption of glucose requires an electrochemical gradient of high extracellular K+ set up by primary active transport. Absorption of glucose occurs at villi and crypts mainly in the duodenum where amylases break down carbohydrates into glucose. Absorption of glucose occurs at the transporting epithelia in the small intestine and is a secondary active transport that requires a Na+gradient
Transport of glucose across the basolateral membrane of intestinal epithelial cells and into the vascular system requires which of the following conditions to occur? Select one: a. Sodium concentration on the inside of the epithelial cell is equal to that outside the basolateral membrane b. Sodium concentration is higher on the inside of the epithelial cell than on the outside of the basolateral membrane c. Sodium concentration inside the epithelial cell is lower than sodium concentration in the intestinal lumen d. Sodium concentration inside the epithelial cell is higher than that sodium concentration in the intestinal lumen
A chemical called ouabain inhibits the Na/K ATPase (the sodium-potassium pump). What would happen to glucose concentrations in the extracellular fluid (not the gut lumen) after exposure to ouabain, and why? Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause extracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the cell to the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would enhance the active transport of glucose from the gut, thereby increasing glucose in the extracellular fluid.
(b) The GLUT system is highly selective for glucose. It also speeds up the rate of glucose transport across the membrane by as much as 100-fold when compared to the passive diffusion of glucose across a bilayer in the absence of any transport system. While impressive, this rate of transport is much slower than purely diffusion limited rate of movement (ie. the fastest a molecule can move by diffusion). Given this fact, on the blank plot below draw the expected relationship between the rate of GLUT-mediated transport and increasing [glucose]? Use the space below the graph to explain your answer. fast Transport Rate slow low [glucose] high (c) Next, use a dashed line on the same plot above to draw the shape of the curve when the amount of GLUT transporters in the membrane is cut in half. Briefly explain your answer in the space provided below the graph.
Polyethylene glycol (PEG) is a solute that is consumed in order to "clean out" the digestive tract in preparation for a colonoscopy. PEG cannot enter intestinal cells as there is no transport mechanism for it. How would this affect the absorption of water into the small intestine? (assume that it is taken at the correct dose and you are not actually reversing the concentration gradient across the intestinal cells.) Explain your answer in terms of concentration gradients.
When blood glucose level rises, the pancreas secretes insulin, and as a result blood glucose level declines. When blood glucose level is low, the pancreas secretes glucagon, and as a result blood glucose level rises. Such regulation of blood glucose level is the result of A reproduction thermal regulation community homeostasis 2,279 12 tv N MacBook Air DII DD F1 F2 F3 F4 F5 F6 F7 F8 F9 F10 F1 @ %23 24 2 6. %3D * CO
The stomach has two types of exocrine cells, chief cell which secrete an inactive form of the protein degesting enzymes pepsinogen, and parietal cells , which secrete hydrochloric acid that activates pepsinogen.Both cell types have an abundance of mitochondria ATP production.The chief cells need energy to synthesise pepsinogen and parietal cells need energy to transport hydrogen ions and chloride ions from the blood into the stomach lumen.Only one of this cell types has an extensive roung endoplasmic and abandant Golgi stacks. Would this be the chief cells or parietal cells?why?
The stomach has two types of exocrine cells: the chief cells, which secrete an inactive form of the protein-digesting enzyme pepsinogen, and the parietal cells, which secrete hydrochloric acid (HCl) that activates pepsinogen. Both cell types have an abundance of mitochondria for ATP production- the chief cells need energy to synthesize pepsinogen, and the parietal cells need energy to transport hydrogen ions. (H+) and chloride ions (Cl-) from the blood into the stomach lumen. Only one of these cell types has an extensive rough endoplasmic reticulum and abundant Golgi stacks. Would this be the chief cells or the parietal cell? parietal cells.