Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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If a mutation in a sodium channel in an Intestinal epithelial cell caused a marked decrease In the concentration gradient of sodium across the plasma membrane, which of the following would you expect to observe?
- a decrease in Na/K ATPase activity.
- an increase in the movement of glucose across the basolateral membrane to the extracellular space
- an increase in sodium/glucose co-transport into the cell across the apical membrane
- a decrease in cytoplasmic glucose concentration
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- Glucose transporters are either open to the extracellular side or open to the intracellular side of the membrane but never both at the same time. True or False? Movement of an ion against or up its concentration gradient is exergonic. True or False? If an amino acid is transported into intestinal epithelial cells through a transporter that is able to concentrate the amino acid using a sodium ion moving down its gradient, this transporter is an example of primary active transport. True or False? The maximum gradient a primary active transporter can build has a potential energy which in magnitude is greater than or equal to the magnitude of the energy released by ATP hydrolysis. True or False?arrow_forwardFill in the blanks: One example of transepithelial transport is the system in intestinal epithelial cells that includes the in the intestine-facing membrane, the energy facing the blood, allowing facilitated diffusion out of the cell into the blood. requiring and the Na+/glucose cotransporter, Glut2, CFTR O Na+/glucose cotransporter, Na+/K+ ATPase, Glut2 Na+/K+ ATPase, Na+/glucose cotransporter, Glut2 Glut2, Na+/glucose cotransporter, Na+/K+ ATPase O Na+/glucose cotransporter, CFTR, Glut2arrow_forwardTransport of glucose across the basolateral membrane of intestinal epithelial cells and into the vascular system requires which of the following conditions to occur? Select one: a. Sodium concentration on the inside of the epithelial cell is equal to that outside the basolateral membrane b. Sodium concentration is higher on the inside of the epithelial cell than on the outside of the basolateral membrane c. Sodium concentration inside the epithelial cell is lower than sodium concentration in the intestinal lumen d. Sodium concentration inside the epithelial cell is higher than that sodium concentration in the intestinal lumenarrow_forward
- Which of the following statements best describes the absorption of glucose? Absorption of glucose requires digestion by aminopeptidases on absorptive epithelial microvilli before absorption of the carbohydrate smaller units such as glucose. Absorption of glucose requires an electrochemical gradient of high extracellular K+ set up by primary active transport. Absorption of glucose occurs at villi and crypts mainly in the duodenum where amylases break down carbohydrates into glucose. Absorption of glucose occurs at the transporting epithelia in the small intestine and is a secondary active transport that requires a Na+gradientarrow_forwardA chemical called ouabain inhibits the Na/K ATPase (the sodium-potassium pump). What would happen to glucose concentrations in the extracellular fluid (not the gut lumen) after exposure to ouabain, and why? Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause extracellular sodium levels to rise, which would reduce the active transport of glucose from the gut, thereby decreasing glucose in the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would reduce the active transport of glucose from the cell to the extracellular fluid. Ouabain would cause intracellular sodium levels to rise, which would enhance the active transport of glucose from the gut, thereby increasing glucose in the extracellular fluid.arrow_forwardWhich is a correct statement about the Na+/K+ transporter (pump), and its cytology and cellular role? It is found the basal side of intestinal epithelial cells, pumping Na+ out of the cell into the blood. It is found on the plasma membrane of neurons, pumping Na+ into axons from the blood. It is found on the membrane of the lysosome, pumping K+ into the lumen of the lysosome. It is found on the apical side of intestinal epithelia, pumping K+ into the lumen of the intestine.arrow_forward
- How does the Na+/ K+ ATPase play a role in glucose transport? phosphorylates GLUT1 to activate it pumps Na+ across plasma membranes into cytoplasm to activate the sodium-glucose transporter pumps Na+ across basal plasma membrane to the outside of intestinal cells so that co-transport of glucose with Na+ into cytoplasm is facilitated allows for the diffusion of K+ inside of cell so that co-transport with glucose is facilitatedarrow_forwardPolyethylene glycol (PEG) is a solute that is consumed in order to "clean out" the digestive tract in preparation for a colonoscopy. PEG cannot enter intestinal cells as there is no transport mechanism for it. How would this affect the absorption of water into the small intestine? (assume that it is taken at the correct dose and you are not actually reversing the concentration gradient across the intestinal cells.) Explain your answer in terms of concentration gradients.arrow_forwardWhich is not a type of endocytotic vesicular transport? a. engulfment of microorganismsb. nutrient absorption of intestinal cellsc. neurotransmitter released. insulin uptakee. none of the abovearrow_forward
- The stomach has two types of exocrine cells, chief cell which secrete an inactive form of the protein degesting enzymes pepsinogen, and parietal cells , which secrete hydrochloric acid that activates pepsinogen.Both cell types have an abundance of mitochondria ATP production.The chief cells need energy to synthesise pepsinogen and parietal cells need energy to transport hydrogen ions and chloride ions from the blood into the stomach lumen.Only one of this cell types has an extensive roung endoplasmic and abandant Golgi stacks. Would this be the chief cells or parietal cells?why?arrow_forwardSodium/glucose cotransporters on intestinal cells move glucose from the intestinal lumen (low glucose concentration) to inside the cell (high glucose concentration). Which of the following would increase the rate of glucose transport into the cell? a. Increase the intracellular glucose concentration. b. Decrease the extracellular glucose concentration. c. Decrease the extracellular Na+ concentration. d. Increase the extracellular Na+ concentration.arrow_forwardwhat type of glucose transport protein is found in pancreatic beta cells? SGLUT-1 GLUT-2 GLUT-3 GLUT-4 GLUT-5arrow_forward
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