Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?
Huntington disease (HD) is a rare dominant condition in humans that results in a slow but inexorable deterioration of the nervous system. HD shows what might be called “age-dependent penetrance,” which is to say that the probability that a person with the HD genotype will express the phenotype varies with age. Assume that 50% of those inheriting the HD allele will express the symptoms by age 40. Susan is a 35-year-old woman whose father has HD. She currently shows no symptoms. What is the probability that Susan will show symptoms in five years?
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter18: Genetics Of Behavior
Section: Chapter Questions
Problem 14QP: A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known...
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Huntington disease (HD) is a rare dominant
condition in humans that results in a slow but
inexorable deterioration of the nervous
system. HD shows what might be called
“age-dependent penetrance,” which is to say
that the probability that a person with the HD
genotype will express the
with age. Assume that 50% of those
inheriting the HD allele will express the
symptoms by age 40. Susan is a 35-year-old
woman whose father has HD. She currently
shows no symptoms. What is the probability
that Susan will show symptoms in five years?
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