Hox genes regulate the identity of serially repeated structures in vertebrates (a) Wild type (b) Ноха11*/Ноха11%; (c) Hoxa11-IHoxa11; Hoxd11IHoxd11 Haxd11IHaxd11 FIGURE 13-11 The morphologies of different regions of the vertebral column are regulated by Hox genes. (a) In the mouse, six lumbar vertebrae form just anterior to the sacral vertebrae (numbers in red). (b) In mice lacking the function of the posteriorly acting Hoxd11 gene and possessing one functional copy of the Hoxa11 gene, seven lumbar vertebrae form and one sacral vertebra is lost. (c) In mice lacking both Hoxa11 and Hoxd11 function, eight lumbar vertebrae form and two sacral vertebrae are lost. [Photographs courtesy of Dr. Anne Boulet, HHMI, University of Utah; from S. B. Carroll, J. K. Grenier, and S. D. Weatherbee, From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, 2nd ed. Blackwel, 2005.)
Hox genes regulate the identity of serially repeated structures in vertebrates (a) Wild type (b) Ноха11*/Ноха11%; (c) Hoxa11-IHoxa11; Hoxd11IHoxd11 Haxd11IHaxd11 FIGURE 13-11 The morphologies of different regions of the vertebral column are regulated by Hox genes. (a) In the mouse, six lumbar vertebrae form just anterior to the sacral vertebrae (numbers in red). (b) In mice lacking the function of the posteriorly acting Hoxd11 gene and possessing one functional copy of the Hoxa11 gene, seven lumbar vertebrae form and one sacral vertebra is lost. (c) In mice lacking both Hoxa11 and Hoxd11 function, eight lumbar vertebrae form and two sacral vertebrae are lost. [Photographs courtesy of Dr. Anne Boulet, HHMI, University of Utah; from S. B. Carroll, J. K. Grenier, and S. D. Weatherbee, From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design, 2nd ed. Blackwel, 2005.)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
As shown in Figure 13-14, what is the fundamental distinction between a pair-rule gene and a segment-polarity
gene?
Transcribed Image Text:Hox genes regulate the identity of serially
repeated structures in vertebrates
(a) Wild type
(b) Ноха11*/Ноха11%;
(c) Hoxa11-IHoxa11;
Hoxd11IHoxd11
Haxd11IHaxd11
FIGURE 13-11 The morphologies of different regions of the vertebral column are
regulated by Hox genes. (a) In the mouse, six lumbar vertebrae form just anterior to the
sacral vertebrae (numbers in red). (b) In mice lacking the function of the posteriorly acting
Hoxd11 gene and possessing one functional copy of the Hoxa11 gene, seven lumbar
vertebrae form and one sacral vertebra is lost. (c) In mice lacking both Hoxa11 and Hoxd11
function, eight lumbar vertebrae form and two sacral vertebrae are lost. [Photographs
courtesy of Dr. Anne Boulet, HHMI, University of Utah; from S. B. Carroll, J. K. Grenier, and
S. D. Weatherbee, From DNA to Diversity: Molecular Genetics and the Evolution of Animal Design,
2nd ed. Blackwel, 2005.)
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