how this stuttering mechanism can change the number of repeat units at theSSR locus responsible for Huntington disease?

Q: How does pair pulse-facilitation demonstrate Hebb's postulate and why is it transient?    (please…

A: When an action potential reaches the presynaptic terminal, it activates and opens voltage-gated…

Q: describe what is CNVCopy number variant?

A: The human genome consists of 6 billion chemical bases or nucleotides of DNA packed into two sets of…

Q: What characteristics are most commonly found in rho-independent terminators?

A: Terminator is a segment of nucleic acid sequence. In the process of transcription, the terminator…

Q: What is the basis for spectrum karyotyping?

A: Answer: Introduction:  A karyotype is the method of taking picture of chromosomes and to study its…

Q: What is the major function of a Src homology-2 (SH2) domain?

A: It is a structurally conserved protein domain contained within the Src oncoprotein and present in…

Q: which Mechanisms Limit TransposableElement Movement?

A: Transposable elements, also known as jumping genes are short segments of DNA, which have special…

Q: define the term deletion loop

A: Chromosomes are thread-like structures that carry genetic information. Each chromosome consists of…

Q: what is dosage compensation.?

A: Sex of an organism in various species depends on the type and number of sex chromosomes. In species…

Q: What is terminal deletion in genetics?

A: A single break may cause terminal deletion; but, due to the need for specific chromosome tips…

Q: I know the answer is e but can you thoroughly explain the answer choices? like what does…

A: The prokaryotic gene regulation is known as operon system which regulates the transcription of a…

Q: Which of the following results in transcriptional attenuation?

A: In hereditary qualities, attenuation is a proposed mechanism of control in some bacterial operons…

Q: What is the underlying genetic defect that causes xeroderma pigmentosum?How can the symptoms of this…

A: Xeroderma pigmentosum condition is a result of specific mutations in the DNA and it is the autosomal…

Q: Explain the a gain-of-function mutation ?

A: Mutations occur when there is a change in DNA due to damage which can alter the gene expression.…

Q: Explain the Comparison of the regions of human NF1 protein and S. cerevisiae Ira protein that shows…

A: Huge amounts of sequences of DNA have already been determined. The pace at which fresh sequences are…

Q: What is the "common disease, common variant hypothesis for the genetic basis of mental health…

A: Disease is an abnormal unhealthy condition produced in a plant due to defective nutrition, heredity,…

Q: Is Alzheimer’s disease always linked to a mutation in a single gene? Provide evidence that supports…

A: Alzheimer's disease is a degenerative  disease characterized by for formation and deposition of…

Q: What is the genetic basis of the symptoms of Down syndrome?

A: Ans: In humans various diseases or disorders are caused by chromosomal aberrations or mutation in…

Q: What are some limitations in the use of ASOs for exon-skipping therapies in Duchenne muscular…

A: Duchenne Muscular Dystrophy (DMD) is a muscular disease caused by mutations in the dystrophin gene…

Q: How to identify all the somatic mutationswithin tumors ?

A: A somatic mutation is a modification within the desoxyribonucleic acid sequence of a somatic cell of…

Q: function of a Src homology-3 (SH3) domain?

A: Amino acids can be defined as the building blocks that form polypeptides and ultimately proteins.…

Q: Why are maternal effect genes so difficult to identify via mutant analysis?

A: Introduction :- In an offspring , the genes are contributed by both of the parents but the mother…

Q: What do we mean when we say that OC mutations in thelac system are cis-acting?

A: Introduction When a DNA gene is destroyed or altered in such a way that the genetic message carried…

Q: Why is the trp attenuation mechanism unique to prokaryotes?

A: Attenuation is a control mechanism that operates to regulate the expression of genes of an operon.…

Q: How does the nucleotide and amino acid of the taster and non-taster differ at SNP 785?

A: Difference in nucleotide and Amino acids of taster and non-taster at SNP 785.

Q: What is anomic aphasia?

A: The anomia is generally a language disorder - inability to express or communicate. It will slowly…

Q: What is Intron retention type of alternativesplicing ?

A: A portion in mRNA that codes for protein is termed as exon. The non-coding region is termed as…

Q: Among the different types of amino acid substitution (same sense, missense, or nonsense mutations),…

A: Introduction A mutation is a change in the DNA sequence of an organism, either as the result of…

Q: What is frameshift mutation?

A: Mutations are alterations in the genetic material present in the cell of a living organism or of a…

Q: What are long terminal repeat (LTR) ?

A: Long terminal repeat are repetitive sequence of DNA found at the end of pro-viral DNA after reverse…

Q: Briefly explain why CpG islands might have come to be underrepresented in eukaryotic genomes.

A: CpG islands are the sites of methylation on DNA. Methylation of DNA occurs to silence some genes of…

Q: How Mutations at the Huntington disease locusare caused?

A: Huntington disease is an inherited rare disease that progressively degenerates the nerve cells…

Q: Compare and contrast the molecular and phenotypic features of Prader-Willi and Angelman syndromes.

A: Prader villi and angle man syndrome are  imprinting disorders. Both are related to  abnormalities in…

Q: What are similarities between Jacob Syndrome and Patau Syndrome?

A: Jacob Syndrome is a chromosomal aberration caused by the non-disjunction of the Y chromosome. They…

Q: What are non- LTR retrotransposons ?

A: Non-LTR retrotransposons are the ones that comprise genes coding for reverse transcriptase along…

Q: What is the significance of the Philadelphia chromosome, and how is it related to leukemia?

A: Chromosomes are the structures present in the nucleus that appear thread like and contain genes.…

Q: why would a mutation complex 1 usually not result in immediate death ? And while blocking complex IV…

A: Electron transport chain is responsible for the oxidation of NADH and FADH2 which results in the…

Q: What is the major biological function of the Son-of-Sevenless (SOS) protein?

A: The name of this gene was based on the fact that the Sos protein it encoded was found to operate…

Q: What is the hyperchromic effect? How is it measured? What does Tm imply?

A: Biomolecules are the substances present in living cells.

Q: Are there any distinctive features associated with TEs Transposable Elements? What are these?

A: Transposable elements have shaped the genome during evolution, allowing for the development of new…

Q: Explain the Analysis of Neurospora Mutants by Beadle and Tatum ?

A: Neurospora crassa or red mould is a fungi. It can be grown easily in culture medium supplanted with…

Q: Describe and compare the structural features of Ig genesuperfamily constant and variable domains.

A: Immunology is the branch of medical science that deals with the study of the immune system and…

Q: The observation that schizophrenia is associated with duplications of a certain copy number variant…

A: CNV  has been observed in various disorders like AUTISM SPECTRUM DISORDER, SCHIZOPHRENIA,…

Q: How is the alternative splicing of Robo3 temporally regulated during midline crossing?

A: Alternative splicing is a mechanism which increases the complexity of gene functions in many…

Q: What are the effects of deletion mutation?

A: INTRODUCTION: Deletion mutation occurs when a part of DNA is not copied or replicated during the…

Q: Explain the Mutations at the Huntington disease locus are caused by an expansion of a trinucleotide…

A: Huntington’s disease is a brain disorder that is inherited in an autosomal dominant pattern. It is…

Q: Compare and contrast the molecular mechanisms leading to FX syndrome and to FSHMD.

A: Introduction :- A gene originally known as FMR1 gene by scientists and responsible for FXS is…