Concept explainers
What happens to the ends of linear chromosomes in eukaryotes during replication?
How are the ends of eukaryotic chromosomes maintained? What happens when
the process goes wrong?
DNA replication in eukaryotes is a highly regulated process and usually requires extracellular signals to coordinate the specialized cell divisions in different tissues of multicellular organisms. External signals are delivered to cells during the G1 phase of the cell cycle and activate the synthesis of cyclins. Cyclins form complexes with cyclin dependent kinases, which, in turn, stimulate the synthesis of S phase proteins such as DNA polymerases and thymidylate synthase. These complexes prepare cells for DNA replication during the S phase.
Step by stepSolved in 3 steps
- How can the chromatin structure change?arrow_forwardwhy is it more advantageous for the cell to have its DNA fused to the cell wall as opposed to dispersed freely in the cell?arrow_forwardIf a bacterial chromosome were inserted into a eukaryotic cell, would it be stable? Would it segregate like eukaryotic chromosomes do during mitosis and meiosis? Why or why not?arrow_forward
- What Is The Origin Of Replication? How many are found in prokaryotes and how many are found in eukaryotes?arrow_forwardIs eukaryotic DNA single or double stranded?arrow_forwardDNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options: More point mutations will arise in MER-minus yeast. Fewer point mutations will arise in MER-minus yeast as compared with wildtype. Of the total point mutations that…arrow_forward
- What is a bacterial nucleoid? With regard to cellular membranes,what is the difference between a bacterial nucleoid and a eukaryotic nucleus?arrow_forwardWhat type of chromosomal rearrangement occurs If a single chromosome suffers two double-strand breaks followed by DNA repair that fuses the remaining broken ends (nonhomologous end-joining) if the intervening fragment rotates by 180°?arrow_forwardIs the DNA chromosomes replication of prokaryotic cells: bidirectional, semi-conservative, and completely continues?arrow_forward
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education