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What are some of the challenges of using recombinant molecules to treatment of HIV?
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- Why is gap repair synthesis needed during HIV DNA integration?15) Why are viruses an ideal candidate for gene delivery in gene therapy? a) What are TWO limitations of viruses as gene delivery vectors in gene therapy?How does the enzyme reverse transcriptase violate the central dogma of molecular biology in HIV.
- Discuss in detail, how you would produce recombinant protein subunit vaccines for Influenza virus.The same molecular process that causes antigenic drift in HIV can lead to resistance to some antiretroviral drugs used in HIV therapy. Which of the following explains why a combinationdifferent antiretroviral drugs is more effective than a single antiretroviral drug? Select ALL that apply.a).Each antiretroviral drug has a different mechanism of action and targets a different aspect of HIV replication.b).By using 3 different antiretroviral drugs at the same time, it is highly unlikely that a combination of mutations conferring drug resistance will occur at the same time.c)Administering 3 antiretroviral drugs achieves higher levels of each drug than administering just one antiretroviral drug.d).By using 3 different antiretroviral drugs, these drugs are likely to be more effective in inhibiting the same HIV enzyme than one antiretroviral drug.e),Administering 3 antiretroviral drugs is less toxic than administering one antiretroviral drug.What are the important differences among a recombinant liveattenuated vaccine, a vector vaccine, and a subunit vaccine?