Given that only about 1 in 10 cells lodges in thespleen, do these results support the idea that the enrichedpopulation consists mostly of hematopoietic stem cells?
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Given that only about 1 in 10 cells lodges in the
spleen, do these results support the idea that the enriched
population consists mostly of hematopoietic stem cells?
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- t is possible to purify hematopoietic stem cellsusing a combination of antibodies directed against cell-surface targets. By removing cells that expressed surfacemarkers characteristic of specific lineages such as B cells,granulocytes, myelomonocytic cells, and T cells, investi-gators generated a population of cells enriched for stemcells. They further enriched this population for putativestem cells by positively selecting for cells that expressedsuspected stem-cell surface markers. Spleen colony for-mation in irradiated mice by these putative stem cells andthe unfractionated bone marrow cells is shown in FigureQ22–3. Given that only about 1 in 10 cells lodges in thespleen, do these results support the idea that the enrichedpopulation consists mostly of hematopoietic stem cells?What additional information would you need to have tofeel confident that the enriched cells are true stem cells?What proportion of bone marrow cells are hematopoieticstem cells?Regarding the production of monoclonal antibodies, it is CORRECT to state that: * A) Hybridomas are cells generated from the fusion of myeloma cells and cells from animals challenged with the antigen of interest that have the ability to produce antibodies and limited cell proliferation. B) All hybrid cells generated from the fusion of cells from the challenged animal and cells of the myeloma lineage will have the ability to produce antibodies reactive against the antigen of interest. C) The HAT selection medium contains aminopterin, which is an efficient inhibitor of the thymidine kinase metabolic pathway, thus eliminating myeloma cells that are not fused or fused with other cells of the same kind. D) The HAT selection medium contains hypoxanthine, which is an efficient inhibitor of the nucleotide synthesis salvage pathway, thus eliminating cells from the challenged animal that are not fused or fused with other identical cells. E) Hybridomas will produce antibodies with the…Skin cancer carries a lifetime risk nearly equal to that of allother cancers combined. Following is a graph [modified fromK. H. Kraemer (1997). Proc. Natl. Acad. Sci. (USA) 94:11–14]depicting the age of onset of skin cancers in patients with orwithout XP, where the cumulative percentage of skin cancer is plotted against age. The non-XP curve is based on 29,757 cancerssurveyed by the National Cancer Institute, and the curverepresenting those with XP is based on 63 skin cancers from theXeroderma Pigmentosum Registry.
- Why is it important that cell surface markers be similar when transplanting donor tissue into a host? How do the alleles of the glycosyltransferase (GT) gene control the presence of A and B antigens on the surface of red blood cells?Penicillin was first used in the 1940s to treat gonorrhea infections produced by the bacterium Neisseria gonorrhoeae. In 1984, according to the CDC, fewer than 1% of gonorrhea infections were caused by penicillin-resistant N. gonorrhoeae. By 1990, more than 10% of cases were penicillin resistant and a few years later the level of resistance was 95%. Explain the various ways this resistance could be spread among the cells. Could this resistance pass to other infectious bacteria from N. gonorrhoeae?From the MW analysis; are any of the gel and immune-detected bands consistent with what you expect for IgG? Are the gel and immune-detected bands suspected to be IgG consistent in distance migrated with to with respect to the molecular ladder? What is the difference between the whole calf serum and the “purified” lanes? Were we able to truly purify IgG with the magnetic bead protocol?
- The mouse thymus normally contains about 1–2 ´ 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCRa locus are compared with those from TCRb-deficient mice, a striking difference between the two different knockout lines is observed, as shown in the figure below in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCRa-/- to TCRb-/- thymocytes? Which region of the thymus organ would show a dearth of developing thymocytes in the TCRa-/- thymus? Which region in the TCRb-/- thymus?(a) What are the genotypic differences between F- cells, F+ cells, and Hfr cells? (b) What are the phenotypic differences? (c) By what mechanism are F- cells converted to F+ cells? F+ cells to Hfr cells? Hfr cells to F+ cells? wwwWhat genes maintain the pluripotency of PGCs before migration? What will promote their conversion into ESCs?
- In a Cervical Cancer screening program, 500 asymptomatic women were examined using the Pap smear test. 200 of the women who truly had lesions were correctly classified; 14 with lesions were wrongly classified as negative. 253 women who had no lesions were correctly classified; 33 women with no lesions were wrongly reported as positive. (A) Summarise the information provided in an appropirate table. (B) Based on the information above, calculate the Sensitivity, Specificity, Positive and Negative Predictive Values of the Pap smear test.What is the status of tissue engineering and stem cell reseaech in the Philippines. In not more than 2 two paragraphs, DESCRIBE THE STATUS OF TISSUE ENGINEERING AND STEM CELL THERAPHY IN THE PHILIPPINES.Hemoglobins from two individuals are compared by electrophoresis and by fingerprinting. Electrophoresis reveals no difference in migration, but fingerprinting shows an amino acid difference. How is this possible?