Give two reasons why a point mutation in the codon for methionine (Met) would likely be more serious that a point mutation in the codon for serine (Ser). Explain your answer.

Given the following RNA molecule: 5' -CUUCAGCAC- 3' a. What amino acid sequence is coded for by this molecule? b. What is the amino acid sequence if a mutation converts CAC to AAC f. What occurs when a mutation converts CAG to UAG?

Use this mRNA coding sequence as your starting point. This sequence begins with a start codon and ends with a stop codon, so it is only looking at the region of DNA that directly encodes a protein sequence. 5’-AUGCACAAAUUAGAGUACCCCCCAGGAAGGUAG-3’ Make the following mutation in this sequence by changing/adding/removing only one nucleotide. Make the mutation easy to see (a different color, circled, something like that) 1) A silent mutation that is also a transition

Use the table below to help you answer the following questions. THE CODON TABLE FIRST POSITION SECOND POSITION THIRD POSITION UUU UCU UAU UGU Phenylalanine Tyrosine Cysteine UCC Serine UUC UAC UGC UA UCA UAA Stop UGA Stop Leucine UUG UCG UAG Stop UGG Tryptophan CU CCU CAU CGU Histidine CUC CAC CGC Leucine Proline Arginine CUA CA CAA CGA Glutamine CUG CCG CAG CGG AU ACU AAU AGU Asparagine Serine AUC Isoleucine ACC AAC AGC Threonine AUA ACA AAA AGA Lysine Arginine AUG Methionine Start ACG AAG AGG GUU GCU GAU GGU Aspartate GUC GCC GAC GGC Valine Alanine Glycine GUA GCA GAA GGA Glutamate GUG GCG GAG GGG Original DNA DNA TACGCTAT GAG C Protein Methionine-Arginine-Tyrosine-Serine Mutation #3 DNA TACGCTATCGAGC How would describe this mutation? (choose ALL that apply) Substitution Deletion Frameshift Silent Insertion