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Genetic application problems
Two men (Father 1 and Father 2) claim in court the paternity of a child, whose blood group is 0. The mother is from group A, while the possible father 1 is from B and the possible father 2 is from AB. Please explain if this information can be used to indicate which of them is not your father. Come up with possible genotypes for the child, mother, and parents. Explain...
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- Pedigree Analysis Is a Basic Method in Human Genetic: What are the reasons that pedigree charts are used?Question:- Based on your selected mode of inheritance, show the genotypes for the following individuals. [Use these symbols for alleles: if it is autosomal, then use the symbols B - dominant, b - recessive (e.g. BB, bb etc.) if it is X-Linked, then X(B) - dominant, X(b) - recessive, and Y for Y-chromosome (e.g. X(B)X(B), X(B)Y etc.) ] I-1 I-2 II-7 II-8 III-10 III-11 III-12 IV-8 IV-9As a genetic counselor, you may face some ethical dilemmas.Imagine that a couple came to your office to discuss potential color blindness in their children.The man is not color blind, but his wife is. They already have one daughter that is color blindand want to know the probability of future children having the disorder. First, you will need toexplain to the couple the difference between sex chromosomes and autosomal chromosomes andthat color blindness is caused by a recessive mutation in a gene found on the X chromosome.Once they understand this, you can then explain to them the probability of other offspring havingthe disorder. What is the dilemma in this case and why might you need to suggest to the couplethat they see a marriage counselor
- Normal wife Affected husband As a genetic counsellor you are presented with a married couple where one of them has a family history of this disease. The husband is affected by this disease and the wife is normal. The couple, who are thinking of starting a family, would like to know what their chances are of having a child born with this condition. They would also like to know what the probabilities are of having an affected boy or affected girl. Use the symbols above to complete the diagram right and determine the probabilities stated below (expressed as a proportion or percentage). Parents 4. Determine the probability of having: Gametes (a) Affected children: Possible (b) An affected girl: fertilizations (c) An affected boy: O O O O Children Affected aite if 耳Paragraph Styles Dictate Sensitivity Font Editor I You breed two monster parents (green, hairless) GGhh and ggHH (white, hairy) to produce F1 offspring (green, hairy). Genes G and H are on the same chromosome. a. What are the dominant phenotypes? b. What are ALL of the potential gamete genotypes that could be created by an F1? Clearly indicate the recombinant genotypes. C. Explain how recombinants are created. What are the potential offspring genotypes from the cross of a F1 monster with a homozygous recessive monster. From this test cross you get 152 green, hairless; 23 green, hairy; 148 white, hairy, and 27 e. white, hairless. Calculate the chi squared to test the independent assortment hypothesis and determine if these genes assort independently. d.The Meeting Sarah stared blankly at the blue paisley wallpaper. Her husband Mike sat by her side, bending and unbending a small paper clip. “Sarah and Michael, it’s good to meet you,” welcomed the genetic counselor, as she entered the room. “I apologize for being late, but I was just meeting with another couple. Let’s see, you’d like to have a child, but you’re concerned because of your family history of cystic fibrosis.” “Yes,” Sarah replied softly. “Mike and I met at a CF support group meeting a few years ago. He had a younger brother who died of cystic fibrosis, and I had a younger sister. We saw the painful lives they had—difficulty breathing, the constant respiratory infections. Although the treatments for CF are better now, we just don’t know if we can…” she trailed off. “I can certainly understand your concern,” the genetic counselor responded sympathetically. “That’s where I hope to help, by providing as much information and advice as I can. I’m glad that you came to see me…
- The world can be a scary place. There are many disease causing organisms and genetic disorders that can make life difficult. As you read the chapter, be thinking about your family history of genetic disorders, how these disorders are passed on through generations, and what types of testing can be done to look for these alleles. In this exercise you will reflect on the pros and cons of genetic testing and how it may affect you. Please remember to add a question to engage your classmates in the discussion. What might the consequences be of having this information (e.g. health insurance coverage, privacy, etc.)?URGENT PLEASE HELP A researcher crosses mice with brown eyes and long tails, and the F1 progeny were recovered in the following numbers and phenotypic classes:F1: 6 apricot, short : 30 brown, long : 15 brown, short : 9 apricot, longYou know the genes encoding these traits are autosomal, completely dominant and assort independently. You want to use a chi-square test to analyse these results.a) Making use of the appropriate genetic convention for naming alleles, give the genotype of the male parent in this cross. b) What is your null hypothesis for the chi-square test? c) Give the expected number of individuals in the “brown, long” class.Problem) A university student is studying the inheritance of 2 genes of pea plants. Color of plant: Blue is dominant (B), and yellow is recessive (b) Spikes or no spikes: Having spikes is dominant (G), and having no spikes is recessive (g). Which of the following findings would indicate to the student that these two traits are located close together on the same chromosome? a) The traits show independent assortment b) All gametes of a double heterozygous individual (BbGg) are either BG or bg c) A double heterozygous individual has four types of gametes in approximately equal proportions: BG, Bg, bG, and bg d) Student finds that there is frequent crossing over between the 2loci
- Sample problems related to non Mendelian inheritanceRead, analyze and answer completely the following problems: 1. Explain why it is possible for the proband in the following pedigree to have children of blood types A, B, and AB. Considering epistatic genes, what are the possible genotypes of II-2? 2. Agouti (A) is wild type and produces alternating bands of pigment on each hair. Black (a) is recessive to agouti. A mutation on gene B (recessive b) can eliminate all color. In a cross between agouti (AABB) and albino (aabb) mice, what genotypes, phenotypes, and proportions are expected in the offspring in F1 and F2 generations?D) Genetics Problem show the table and word In certain breeds of chickens, the allele "B" is responsible for black feathers whereas the contrasting allele "b" produces feathers that are white. Another r pair of alleles influences the shape of the feathers. "F" produces straight feathers whereas the contrasting gene for "f results in the frizzled condition. Give the genotypic and phenotypic ratios to be expected from the following cross: white, frizzled hen with a heterozygous black, homozygous straight rooster. Genotypic Ratio: Phenotypic Ratio:Non- Mendelian patterm of inheritance. Activity 4: What's your blood type? Objective: Infer the unknown phenotypes of individuals on the basis of the known phenotypes of their family members Procedure: A. Given the blood types of the mother and the child, identify the possible blood type of the father. Mother's Blood type Father's Blood type Child's Blood type A B AB AB