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General properties of Sex-linked Inheritance, traits is always passed from the father to son and only males are affected. *
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- Mendel’s observation that two different traits could be inherited independently of each other can be explained by understanding that: During meiosis, the process of chromosome assortment into daughter cells is random Alleles of the genes reside on homologous chromosomes All of the listed choices are correct During meiosis, maternal and paternal members of homologous chromosomes are distributed separately into daughter cellsHemophilia is a typical example of Sex-Linked Inheritance. If the man is hemophilic and marries a homozygous normal woman. What will be the genotype of the female child?Mendelian Genetics and Non-Mendelian Genetics: Huntington’s disease, a neurodegenerative genetic disorder that typically becomes noticeable in middle age, is due to an autosomal dominant allele. Sickle cell anemia, on the other hand, is a genetic blood disorder due to a recessive allele. Jillian is a carrier of the allele for sickle cell anemia but has no sign of any neurodegenerative disorder in her family. She married Jacobwhose father died of Huntington’s disease. His mother, however, is not inflicted with that condition. Neither of his parents exhibit sickle cell anemia. 1. Give the genotypes of Jillian and Jacob. Assuming that they will have 4 children, what is the probability that: 2. all their children will be normal? 3. they will have a son with Huntington’s disease? 4. they will have a daughter inflicted with both conditions
- Why do human sex-linked recessive traits typically show up in sons more than daughters? Hint: consider the probabilities involved in the inheritance of such traits.A mother who is heterozygous for Huntington’s disease (child from mother in #8) and a father who is homozygous normal want to have a baby. What genotypes and phenotypes are possible for their child?Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Usher’s Syndrome is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. One website (http://www.emedicine.com/oph/topic704.htm) says that Usher’s Syndrome Type II has been mapped to chromosome arm 1qe. Usher’s Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition 1) Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Within this pedigree, include Eric's parents, Eric himself, Eric's brother Dirk, and a daughter of Eric's. Be sure to follow all standard pedigree conventions. 2) Imagine you are a genetics counselor. Based upon the pattern of inheritance, what advice would you give Eric's…
- A woman with Huntington’s disease (autosomal dominant trait, and she is heterozygous) has children with a healthy man. What proportion of their children will inherit Huntington’s disease?For a recessive X-linked mutation, such as colorblindness, explain the pattern of inheritance from anaffected male through his daughters into her children.Genes involved in sex-limited inheritance are found in autosomal genes? True or false
- Why is sex-linkedinheritance an example ofnonmendelian inheritance?Indicate the nature of the trait and type of inheritance involved in each of the following situations. (a) Children who exhibit this trait have at least one parent who exhibits the same trait. (b) Children exhibit this trait even though neither parent does.If there is a possibility of four different genotypes in the offspring that result from a dominant-recessive inheritance, and if the couple has four children, would they definitely have children with one expressing each genotype? Explain.