For decades scientists have been perplexed by different circumstances surrounding families with rare, early-onset auditory neuropathy (deafness). In some families, parents and grandparents of the proband have normal hearing, while in other families, a number of affected (deaf) family members are scattered throughout the pedigree, appearing in every generation. Assuming a genetic cause for each case, offer a reasonable explanation for the genetic origin of such deafness in the two types of families.

Based on the information shown (picture) draw the pedigree for this family in the space provided below. Make sure to indicate Lee, the proband, with an arrow and use the proper svmbol for individuals who have died from cancer. Remember to also label each generation with roman numerals.

In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COL1A1) gene are present in an individuaľ's chromosome 17. a. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (OI) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Ol. What is the genotype of... a.1. the man's father? a.2. the man's mother? b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by showing…

This is a pedigree for a dominant trait caused by gene A in humans. Shaded symbols show individuals affected with the trait; non-shaded individuals are normal (aa). Among the progeny arising from the marriage of individual III-1, what proportion would be expected to show the trait?  Among the progeny arising from the marriage of individual III-6, what proportion would be expected to show the trait?