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A. Explain the concept of selective toxicity. Why antimicrobial drugs work best against bacteria which are actively reproducing?
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- Explain different type of chemotherapeutic agents.Discuss gout by focusing on the following aspects: general symptoms, metabolic pathway and intermediates involved, pathogenesis and treatment.Describe the advantages and disadvantages associated with the use of antibiotics, including overuse and abuse of antibiotics, development of drug resistance, superinfections, and antibiotic-associated colitis
- b. Which chemotherapeutic drug above (A, B, C, or D) is most effective against Staphylococcus aureus, if possible? Explain your answer.A. What is the difference between a pathogen’s infective dose(ID50) and lethal dose(LD50)? B. Which is more closely related to the severity of a disease?а. What is a drug target? Why is it important to identify a drug target to treat a disease?
- Explain the concept of selective toxicity in terms ofantimicrobial therapy.explain how the different targets of antimicrobial drugs work in relation to selective toxicity.b. You are working to develop drugs that can target bacterial infections or fungal infections. Please describe 2 differences in the cell wall structure that could aid in cell-specific drug development. ** c. You have identified a new gram-negative bacterial species and have been tasked with determining antibiotic susceptibility. Please name 2 antibiotics you would try to target a gram-negative bacterium. Please explain why you chose them.
- How does fluid restriction work as a therapeutic intervention for a patient with heart failure? Please explain detailed pathophysiologyExplain the two major classes of biologic response–modifying drugs: hematopoietic drugs and immunomodulating drugsDefine risk. Use a single dose response graph to compare the relative risk associatedwitha) a PCB; b) 2,3,7,8-TCDD; and c) exposure to radiation.