Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- You have a neural system with three neurons; two presynaptic (PS1 and PS2) and one postsynaptic (Post). Over a fixed period of time, PS1 and PS2 generate the pattern of action potentials. Both deliver the same pattern. PS1 delivers EPSP to Post and PS2 delivers IPSP to Post. Also present in the system is a chemical that inhibits the binding of PS2's neurotransmitter to Post's receptors. Will Post be likely to produce an action potential in response to this situation?arrow_forwardWhich of the following statements are true with regards to the differences between a neuromuscular junction, and a standard central nervous system (CNS) synapse? Select all that apply. O The neuromuscular junction is a synapse between a neuron (alpha motor neuron) and a muscle fibre. CNS synapses connect two neurons. The graded potential generated by a neuromuscular junction has a much larger voltage than that of a CNS synapse. The structure of the neuromuscular junction ensures that an action potential in the alpha motor neuron always results in an action potential in the post-synaptic muscle fibre. CNS synapses do not guarantee this. The neuromuscular junction always uses Acetylcholine as a neurotransmitter, whereas CNS synapses may use a variety of neurotransmitters depending on their location and functionarrow_forwardDopamine is a neurotransmitter produced by the nervous system that is involved in the pleasure/reward system in the brain. The release of dopamine in response to a stimulus produces feelings of happiness and satisfaction. Cocaine is a type of drug that affects the brain response to dopamine. Usually after dopamine is released into the synaptic cleft, it is quickly re-absorbed into the neuron using dopamine transporters. However, cocaine blocks these transporters which causes dopamine to remain in the synaptic cleft for a long period of time. How would this impact the neuron's ability to communicate? Neurons will produce smaller action potentials because more dopamine is binding to receptors on the neuron, preventing the neuron from reaching the threshold potential Neurons will be under-stimulated because dopamine will bind to receptors and prevent ions from moving into the neuron, preventing electrical signaling Neurons will produce larger action potentials because more dopamine is…arrow_forward
- Excitatory neurotransmitters open up some sodium ion channels in the postsynaptic dendrite. This allows some sodium ions (Na+) to enter the postsynaptic dendrite, making the membrane potential more positive and bringing it closer to the threshold potential. This increases the likelihood of an action potential. Inhibitory neurotransmitters open up ion channels in the postsynaptic membrane for positive potassium ions (K+) to flow out OR negative chloride ions (Cl-) to flow in. Whether potassium ions go out or chloride ions go in, the postsynaptic cell becomes more negative than the resting membrane potential (further from the threshold potential). This decreases the likelihood of an action potential. The effect of the inhibitory neurotransmitter on the postsynaptic membrane is to a. maintain the resting potential b. hyperpolarize the postsynaptic membrane c. depolarize the postsynaptic membrane d. decrease the threshold levelarrow_forwardIf a neuron is stimulated simultaneously by 2 stimuli at its dendrites (one generates a very large hyperpolarizing potential and the other generates a very small depolarizing potential). What would happen to this neuron? Group of answer choices The summation of these two graded potentials will generate an action potential and this action potential will travel down the axon. Summation of these two graded potentials will cause the membrane potential at the axon hillock to be more negative. These graded potentials will bring the resting membrane potential to 0 mV. These graded potentials with opposite polarity would therefore generate two action potentials and they will travel along this neuron in opposite direction.arrow_forwardFor the nervous system to convey information using electrical signals, the signals typically must be passed from one neuron to another. Oftentimes, this transfer of information across the synapse occurs via the release of neurotransmitters from the pre-synaptic terminal. When a large stimulus is detected in one neuron, it often conveys this information by releasing a larger amount of neurotransmitter into the synapse.arrow_forward
- The normal concentrations for intracellular and extracellular potassium in a neuron are [K+]in = 150 mM and [K+]out = 5 mM, respectively. Due to an electrolyte imbalance, a patient has the following intracellular and extracellular concentrations of potassium: [K+]in = 140 mM and [K+]out =2 mM. Using the Nernst equation (Chapter 4), calculate the equilibrium potential for potassium in the cells with normal K+ distributions and of the diseased patient. Refer back to Question #1. Will it be easier or more difficult to generate an action potential in the diseased neuron as compared to the normal neuron? Why?arrow_forwardAssume a neuron is at rest and the following changes happen: Step 1: Neurotransmitter binds to an ionotropic excitatory neurotransmitter receptor causing an EPSP. Step 2: With the neurotransmitter still bound either a NAM or non-competitive antagonist bind to the allosteric site of the receptor. Answer the following questions that explains how the NAM and non-competitive antagonist would differ in their actions. 4.) A. Going from step 1 to step 2 what would happen to the ionotropic receptor (ion channel) as a result of the NAM. B. Going from step 1 to step 2 what would happen to the ionotropic receptor (ion channel) as a result of the non-competitive antagonist. C. Going from step 1 to step 2 how would membrane potential change as a result of the NAM D. Going from step 1 to step 2 how would the membrane potential change as a result of the non-competitive antagonist.arrow_forwardDraw a presynaptic and postsynaptic neuron at to demonstrate the release and acceptance of a neurotransmitter. Identify the following in your drawing: Ca2+, synaptic cleft, receptor, synaptic vessicle, SNARE, presynaptic neuron, postsynaptic neuronarrow_forward
- Describe at least 2 processes at the synapse that shift the effect of an action potential of a pre synaptic cell on the response of a post synaptic cell.arrow_forwardWhen an impulse arrives at the synapse, the synaptic vesicles open and release neurotransmitters into the cleft within a thousandth of a second. Within another ten thousandth of a second, these molecules have diffused across the cleft and bound to receptor sites in the effector cell. In what two ways is transmission across a synapse terminated so that the neuron’s signal is concluded?arrow_forwardPlease answer question 32arrow_forward
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