Discuss the principles of Thiobarbituric reactive species (BARS) assay
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Discuss the principles of Thiobarbituric reactive species (BARS) assay
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- Briefly outline &/or sketch the premise of the transwell assay:State the principle that underlies the following biochemical tests: a. Voges-Proskauer testBased on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives. The given question to me is: What is a pharmacopeial monograph? Based on the USP XXII and NF XVIII, list the part of a monograph of the following: crude drug, natural product, and natural derivatives.
- Biotransformation is an important concept in pharmacology, which amongst others, enables the effective administration of prodrugs. Provide a detailed description of factors influencing the biotransformation of drugs.A patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…Description of clinical trial process for the Pfizer-BioNTech. Incorporate the following key words: Length of trial; population diversity; efficacy; side effects Pfizer-BioNTech
- How we can improve these parameters(isomerism, isosteric replacement) for the development of H1-Antihistamine drugs?Drug substances are useful based on their biological activity. Thus, an assay must be developed to ensure that this important function is preserved during purification. There are three major types of biological activity assays including animal model assays, cell-line-derived assays, and in vitro biochemical assays. Please find an example of each (in literature, online, etc.) and briefly Include a reference for each (no particular reference format required, can simply include a web link if easiest).What is DPI? What are the advantages of DPI over MDI? How drug is aerosolized from a DPI system? Please answer at your own words.
- What is MDI? Briefly Discuss the formulation and drug aerosolization process from a MDI? please discuss at your own words.How to test in vitro metabolic stability of new drug molecules?Detail of basic steps involved in synthesis of a recombinant drug product. Justify by manufacturing protocol of recombinant insulin.