Discuss about Cdc25 phosphataseactivates mitotic CDKs,which activate earlymitotic events
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Discuss about Cdc25 phosphatase
activates mitotic CDKs,
which activate early
mitotic events
Step by step
Solved in 2 steps
- Diagram (just use arrows in the same way you diagrammed in a former test a stimulus leading to the activation of PKC, for example) in as much detail as possible what happens to a mammalian cell when it is irradiated, leading to when the cycle stops due to DNA damage. Include and name the famous mammalian checkpoint protein known by its molecular weight, as well as name another protein it activates. This other protein's function can be described by a 3 letter acronym that contains the letter K. Mention the acronym. 1.Notch signaling orchestrates transition from G1 to S phase of cell cycle by multiple other interactions that target the G1/S checkpoint machinery. This is a highly conserved pathway that is seen across multiple kingdoms of life and the ligands involved in notch signaling are typically membrane-bound proteins. This suggests that: -This pathway relies on hormone interactions via endocrine pathways -This pathway relies on signal propagation via paracrine molecules -This pathway relies on direct signaling across gap junctions -This pathway relies on cell binding via autocrine signalingWhich of the following is false about cyclin-cdk complexes? OCdk's do not have to bind to cyclin proteins for complex to be active. OCdk/cyclin complexes phosphorylates proteins required to trigger next cell cycle phase. Process acts as molecular brakes to ensure cell is ready to continue with cell cycle. O Cyclin concentrations increase gradually, but cdk must be phosphorylated by specific kinase for complex to be active
- There is now significant evidence to support the existence of cytoneme-mediated delivery of signaling ligands. What is their mechanism of action, and what is the relevance of this discovery to embryonic development?1117 increase in the number of passive glucose transporter on the muscle cell surface thus increases the uptake of glucose into the cell and decreases blood glucose level. Indicate whether the following conditions/practice will likely lead to diabetes (mark Yes or No). [Select] a mutation in a V-SNARE in islet cells that blocks all secretion Q Search ******* 40 ****** 99+ app.honorlock.com is CDescribe the effects of the over-expression of mdm2 on cell proliferation and apoptosis on cell signaling pathways and metabolism or cell cycle control. Briefly explain the normal role of each component in the context of the pathway and why its loss or modification would have the expected effect.
- In attempting to design a drug that will impede cell cycle progression in ovarian cancers cells. you will want the drug to have this effect on the cells; Group of answer choices Increase expression of CDK7 Increase the phosphorylation of the ATP-binding pocket of CDK1 Increase expression of CDC25A All of theseTSC acts as a tumor suppressor by continually suppressing mTOR and must be inhibited in order for mTOR to be active. True or false, explain whyA temperature-sensitive mutant yeast strain stops dividing when shifted from 25°C to 37°C. These cells are analyzed at different temperatures by a machine that measures the amount of DNA they contain, and the following graphs are obtained. number of cells number of cells [ Select] [Select] [Select] 25°C [Select] مل Cells in G1 phase should have [Select] Which of the following would explain the behavior of your mutant? Mark yes or no for each of the following choices. 2 amount of DNA/cell (arbitrary units) 37°C 1 2 amount of DNA/cell (arbitrary units) unit(s) amount of DNA. ✓ Inability to initiate DNA replication Defect in chromosome condensation ✓Defect in centrosome duplication ✓Defect in cytokinesis
- Changes in the activity of a variety of Cdks are essential for accurate progression through the cell cycle, and yet the levels of Cdk expression are fairly constant during the cell cycle. Briefly describe three mechanisms by which the activity of Cdks is regulated.Indicate whether each of the following statements related is likely to be true or false Similar to the Cdks, when activated, the anaphase-promoting complex phosphorylates its targets. The level of M-cyclin is constant throughout the cell cycle.Discuss the relationship of the Bcl-2 family, caspase family, and mitochondrion in apoptosis.