Devise a solid-phase synthesis of the Ala-Leu-Val-Phe-Met, using Fmoc protection and the Chlorotrityl or Wang resins .
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Devise a solid-phase synthesis of the Ala-Leu-Val-Phe-Met, using Fmoc protection and the Chlorotrityl or Wang resins .
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- Extracting DNA From Strawberries Is isopropyl alcohol polar or nonpolar? ExplainOutline the key strategy used to reduce the sensitivity of the beta-lactam ring of a penicillin to hydrolysis, illustrating your answer by describing three examples of structural modification.Why 14C@phenylalanine is used ?
- Devise a solution-phase synthesis of Ala-Leu-Val-Phe-Met, starting from the requisite Boc-protected amino acidConsidering the general structure of penicillins, how are they rendered ineffective? Select one: O a B-Lactamase performs nucleophilic attack of the amide in the penicillin side chain Ob. B-Lactamase performs nucleophilic attack of the amide in the B-lactam ring and subsequently hydrolyzes this intermediate OC. B-Lactamase performs nucleophilic attack of the thiazolidone ring on the carbon next to the electronegative sulfur leading to a covalently inhibited B-Lactamase o d. All of these O e. None of theseFibrinogen contains tyrosine- O - sulfate. Propose an activated form of sulfate that could react in vivo with the aromatic hydroxyl group of a tyrosine residue in a protein to form tyrosine- O -sulfate.