Describe which neurotransmitters and receptors are involved in the various switches (synapses) in the sympathetic and parasympathetic parts of the autonomic nervous system
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Describe which neurotransmitters and receptors are involved in the various switches (synapses) in the sympathetic and parasympathetic parts of the autonomic nervous system
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- Nervous system functions that directly employ acetylcholine neurotransmitters are referred to as cholinergic. Drugs that might be therapeutic in treating the symptoms of dopamine loss in Parkinson’s disease could include multiple choice 1 dopaminergic agonists and cholinergic antagonists. dopaminergic antagonists and cholinergic antagonists. dopaminergic antagonists and cholinergic agonists. dopaminergic agonists and cholinergic agonists. 2. From the information provided, drugs used to treat Parkinson’s disease symptoms will act at which location? multiple choice 2 The globus pallidus The substantia nigra The striatum 3. Which of the following might be therapeutic in the treatment of Parkinson’s disease symptoms? multiple choice 3 all of these choices listed may be therapeutic increasing dopamine receptor responsiveness monoamine oxidase inhibition increasing dopamine release decreasing dopamine…Depression is a condition in which sufferers may feel low mood, lack of motivation and sleep. It is caused by a lack of serotonin in the synaptic cleft of neurone pathways. Serotonin is a neurotransmitter. a) Describe how serotonin acts as a neurotransmitter. Using your understanding of synaptic transmission, explain how communication between neurones in serotonin pathways of the brain would be affected in someone with depression. b) Doctors use tubocurarine drug as an anaesthetic as it temporarily paralyses muscles. It blocks receptors at neuromuscular junctions. Why does this lead to paralysis?Draw a chain of two neurons that synapse on one another in sequence. Label the presynaptic and postsynaptic ends of each neuron, the cell bodies, dendrites, axons, axon hillock and axon terminals, location of voltage gated Ca²+ channels, location of voltage gated Na+ channels, location of voltage gated K* channels, location of Na*/ K+ pumps, location of neurotransmitter storage, location of neurotransmitter receptors. Consider your drawing and describe the function of neurons. Include an explanation why neurons are considered polarized cells and how this relates to their function. (Polarized here is not referring to membrane potential as all cells have a membrane potential). This means you will need to explain the location of different channels in the neuron and the relationship of the channels to the function of a neuron.
- Name the neurotransmitter released at each synapse or neuroeffector junction in the somatic and autonomic systems?Draw a presynaptic and postsynaptic neuron at to demonstrate the release and acceptance of a neurotransmitter. Identify the following in your drawing: Ca2+, synaptic cleft, receptor, synaptic vessicle, SNARE, presynaptic neuron, postsynaptic neuronList the synapses in which ACh is the neurotransmitter.
- What type of synaptic potential (if any; be sure to indicate if any modification is occurring as well) would occur if: a.) An MAO inhibitor type of antidepressant is functioning at an active dopaminergic synapse that increases the rate of sodium flowing into the cell. b.) Prozac is present at an active serotonin synapse where receptor activation increases the flow of potassium out of the cell.Select all of the statements from the list below that are true. Within a single axon, an action potential is always of the same magnitude. (In other words, it always looks the same on a trace of the membrane potential.) All excitatory post-synaptic potentials trigger an action potential. Graded potentials are always hyperpolarizing. The action potential always moves in one direction along an axon. Integration of sensory information is a major function of the central nervous system. All axons in the body are myelinated.Cocaine blocks the removal of dopamine from the synapse, leading to a rapid rise of dopamine in the synapse. Which of the following best describes what will likely occur as a result of increased dopamine in the synapse? The presynaptic cell will be unable to release more neurotransmitter. the postsynaptic cell will return to its resting potential, causing feelings of well-being. The postsynaptic cell will be constantly activated, causing feelings of euphoria. The postsynaptic cell will respond more quickly to a change in output of the presynaptic cell, causing feelings of euphoria. The buildup of neurotransmitter will activate the presynaptic cell, causing feelings of euphoria.
- The following diagram represents a typical serotonergic synapse. Where, specifically, do antidepressants work (e.g. SSRI)? Neurotransmitter Neurotransmitter transporter Аxon Synaptic vesicle terminal Voltage- gated Ca?+ channel Synaptic cleft Receptor Postsynaptic density Dendrite Neurotransmitter Synaptic Vesicle Neurotransmitter transporter (aka Reuptake transporter) Receptor O All of the aboveWhich of the following are the likely explanations for the failure of a postsynaptic neuron to trigger an action potential? Select all that apply. The EPSPs are neutralized by the neurotransmitter The summation of IPSPs and EPSPs is insufficient to depolarize the cell to threshold The synapses generating the EPSPs are too close to the axon hillock The synapses generating the EPSPs are too far from the axon hillockSpastic paralysis (resulting from the failure of muscles to relax), induced by the neurotoxin strychnine, occurs when this poison blocks the binding of: the excitatory neurotransmitter acetylcholine to post-synaptic sodium channels the excitatory neurotransmitter glutamate to post-synaptic calcium channels the excitatory neurotransmitter serotonin to post-synaptic potassium channels the inhibitory neurotransmitter glycine to post-synaptic chloride channels the inhibitory neurotransmitter melatonin to post-synaptic bicarbonate channels