Answered: Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)

Biochemistry

9th Edition

ISBN: 9781319114671

Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher: W. H. Freeman

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Question

Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)

His 57
Asp 102
C=0
CH
Sor 195
...H-N.
Ni
Gly 193
c=0
...H-N,
(a) Enzyme-substrate complex
..•H-N.
N:
c=0
(b) First tetrahedral
Intermediate
His 57
CH-CH,
Asp 102
c=0
...H-N,
CH,
CH
Ser 195
(c) Acyl-enzyme
......t;N~
C=o*.HN
Gly 193
CH-CH,
c=0
CH
H
(d) Acyl-enzyme
CH-CH,
...H-N.
c=0
CH
(e) Second tetrahedral
Intermediate
H
HO-C=0
The Probaple Mechanism of
CH-CH,
Action of Chymotrypsin.
Es Scanned or scanner
In Enz,m-product
con

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Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)

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