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Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products, compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TsO 2) HO Bn Decytonpolide A H Decytospolide R- COCH

Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products, compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TsO 2) HO Bn Decytonpolide A H Decytospolide R- COCH

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products. compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TeO 2) H0 Bn Decytonpolide A R-H) Decytospolide R- COCH) 13.25 a 13,25 d Incorrect. Add curved arrow(s) to draw step 1 of the mechanism for the conversion of compound 2 to compound 3 (note that the Grignard reagent is represented as a carbanion). Modify the given drawing of the product as needed to show the intermediate that is formed in this step. Edit Drawing Hint
Transcribed Image Text:Decytospolides A and Bare fungal natural products that are toxic to some cancer cells, In a synthesis of these natural products. compound 3 was prepared via the reaction between an epoxide (compound 2) and a Grignard reagent (Tetrahedron: Asymmetry 2015. 26, 296-303). Draw the structure of 2, and provide a complete mechanism for the conversion of 1 to 3. OBn OBn NaH TeO 2) H0 Bn Decytonpolide A R-H) Decytospolide R- COCH) 13.25 a 13,25 d Incorrect. Add curved arrow(s) to draw step 1 of the mechanism for the conversion of compound 2 to compound 3 (note that the Grignard reagent is represented as a carbanion). Modify the given drawing of the product as needed to show the intermediate that is formed in this step. Edit Drawing Hint
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