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A male individual who is XYSRY has the following genotype for the AMH gene on chromosome 19: AMH1 AMH2. The AMH1 allele codes for a protein that is capable of binding to the receptor for AMH. The AMH2 allele codes for a protein that is unable to bind with the receptor for AMH.
- Based on your understanding of biology, what is the likely
phenotype of this individual?
Humans have 23 pairs of chromosomes of which 22 pairs are autosomal and the 23rd pair is sex-linked.In a human female, the sex chromosome pair is represented as XX, whereas, in a human male, it is represented as XY.AMH is an anti-Mullerin hormone produced by the Sertoli cells in males and helps in the development of the sex organs. Each pair of chromosomes has a pair of genes called alleles at the same loci representing a single character. Each gene of an allele represents the expression of the character.A gene can either show expression or inhibition of the character .
- In the case of the AMH gene present on chromosome 19, the two genes are AMH1 and AMH2.
AMH1 represents the expression of the character as it allows the binding of the protein to the receptor and AMH2 represents the suppression of the character.
- Of the two alleles, the one that allows the expression should be dominant over the one that suppresses.
Also, it is possible that AMH2 is a result of a mutation in the DNA and mutated genes are recessive.
According to the law of dominance stated by Mendel, When the alleles are heterozygous (consisting of the alleles with opposite characters) the character represented (phenotype) is the one according to the dominant allele.
Hence, the phenotype of the individual will be the binding of the protein to the AMH receptor.
- Create a box-and-arrow model that describes:
- how information in the AMH gene results in the phenotype you identified, above, and
- the origin of the
genetic variation in this system.
Your model should include the following core structures, contextualize to this case, although you may add or repeat structures as needed:
allele, amino acids, gene,
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