Could the characteristic followed in the pedigree be caused by an autosomal dominant disease? Why or why not? ONo, the offspring of 1-3 and I-4 contradict an autosomal dominant inheritance ONo, the offspring of 1-1 and I-2 contradict an autosomal dominant inheritance O Yes, all individuals fit the autosomal dominant inheritance pattern No, the offspring of -3 and 1-4 contradict an autosomal dominant inheritance
Q: Shaded in black-white trait (Glucose-6-phosphate dehydrogenase deficiency) 1. What type of x-linked…
A: Answer 1- The type of x-linked inheritance is shown in the chart above is : b. X linked recessive…
Q: What is the most likely mode of inheritance in this pedigree? ? O Y-linked O Mitochondrial O…
A: Pedigree is the diagrammatic representation of trait of individuals in a family.
Q: The individuals with a certain disease are shown in this pedigree. The disease is caused by an…
A: By analyzing a pedigree, we can determine genotypes, identify phenotypes, and predict how a trait…
Q: For each of the listed modes of single gene inheritance (assuming complete penetrance), indicate…
A: As per our guidelines we are supposed to answer only first three sub-parts. Kindly repost the…
Q: A woman with type O blood has a son with type A. What are ALL the possible genotype(s) a possible…
A: ABO blood group determines the type of blood group a person has. Persons may have type A, type B,…
Q: I. 1 2 4 II. 1 3 III. In the pedigree above, there could be carriers that are not marked. For each…
A: The pedigree analysis helps in identifying the mode of inheritance of a particular disease in a…
Q: Assuming complete penetrance, which type of inheritance pattern isconsistent with the pedigree shown…
A: Introduction: Genetics is the study of genes and the roles they play if inherited into the…
Q: Albinism, lack of pigmentation in humans, results from an autosomal recessive gene Two parents with…
A:
Q: What is the inheritance pattern shown in the above pedigree? O autosomal recessive O sex-linked (X)…
A: Pedigrees are constructed based on the inheritance pattern of different traits, through several…
Q: Albinism, lack of pigmentation in humans, results from an autosomal recessive gene (a). Two parents…
A: Albinism - Albinism is a kind of rare genetic disorder. It reduces the pigmentation of the skin. It…
Q: In general patterns of sex-linked Inheritance, the affected males produce all affected female…
A: NOTE: Kindly repost for other questions Dear Student as per the guidelines we are supposed to answer…
Q: There are several possible modes of inheritance through which traits can be inherited. The following…
A: Pedigree is defined as the family representation for a particular trait.
Q: Which of the following mode of inheritance most likely to representthe pedigree showing the pattern…
A: The pedigree is the family tree diagram used to represent the pattern of inheritance in the family.…
Q: What is the mode of inheritance of rare Marfan based on the given pedigree? I ☐TO 2 C. Autosomal…
A: Pedigree analysis helps us identifying the inheritance pattern of a particular disease by observing…
Q: Ectrodactyly is a rare condition in which the fingers are absent and the hand is split. This…
A: Ectrodactyly is a genetic disorder which is usually inherited as an autosomal dominant trait. The…
Q: There are two traits not shown in the pedigree: albinism (autosomal recessive) and Marfan syndrome…
A: A pedigree chart is a graphic that depicts the incidence and emergence of phenotypes of a certain…
Q: II 4 5 II 1 2 3 4 5 6 7 IV 1 2 3 4 5 6 7 8 9
A: In the given pedigree, the trait skips generation, i.e., the trait appeared in the first generation…
Q: Suppose a man carries a very uncommon dominant mutation for a deadly muscular disease that doesn't…
A: Introduction: Genetics is one of the most advanced disciplines of science. The field of genetics is…
Q: 2 II 4 5 6. (7) II 8. 9 10 11 12 1314 IV 15 16 17 18 (19 20 The pedigree above traces sickle cell…
A: Genotype: An individual collection of genes is recognized as genotype, while it can…
Q: 16) If this is an autosomal recessive disorder, how many individuals found in the pedigree have…
A: The autosomal recessive disorder occurs if the disease gene is present on nonsex chromosomes,…
Q: What is the mode of inheritance shown in this pedigree? II 1 3. 6. 7. 2 3 5 6 7 8 9 10 IV 1 2 3 5 67…
A: Since they lack a second copy of the X chromosome to give a dominant allele, any XY individual who…
Q: I. 3 4 II. 1 2 3 4 III. In the pedigree above, there could be carriers that are not marked. For each…
A: Pedigree analysis is the diagrammatic representation of the genetic inheritance of a trait of a…
Q: Tay Sachs disease is a recessive lethal. Abnormally shortened fingers are the heterozygous form of…
A: Alleles are the alternative forms of a gene that are located on the same locus of homologous…
Q: Which genotype is indicative of the carriers of a trait associated with an autosomal recessive…
A: Dominant and recessive expression of genes is the most common interaction among genes. When an…
Q: A man and a woman are both carriers for cystic fibrosis (an autosomal recessive allele). Neither of…
A: Introduction Cystic fibrosis is a life-threatening genetic disease that affects the lungs and…
Q: Your sister who taking the genetics course, approaches you with a problem set to solve and seeks you…
A: (a) Autosomal recessive can not be excluded. (b) Autosomal dominant. → Can be excluded. (C)…
Q: John and Maggie are expecting a child. John's great-grandmother (mother's lineage) and Maggie's…
A: Introduction A genetic characteristic or condition can be passed down from one parent to the next…
Q: Pedigree 1: What is the most likely mode of inheritance of this disease given its pattern on the…
A: Pedigree chart shows the inheritance of traits from parents to their offspring.
Q: Pedigree 2: What is the most likely mode of inheritance of this disease based on its pattern in the…
A: what is the most likely mode of inheritance of this disease based on each its pattern in the…
Q: Shaded individuals in this pedigree express a particular trait. Based on this pedigree, what is the…
A: Pedigrees are used to determine how a given trait is inherited within a family. Pedigrees…
Q: What is the most likely mode of inheritance for the trait shown in this pedigree? Normal Carrier…
A: The mode of inheritance is a pattern of obtaining parentral alleles or genes to the offsprings. The…
Q: Pedigree attached shows an autosomal recessive genetic disease. G is the normal allele and g is the…
A: The pedigree study helps us to make conclusion about the inheritance pattern and probability of…
Q: The following pedigree is for a disease that is completely penetrant. For this question,do not make…
A: A pedigree shows the relationship between family members and indicates which individuals have…
Q: Which pattern of inheritance is associated with a trait that (1) is not usually expressed in the…
A: Inheritance is the transmission of traits over generations.
Q: Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for…
A: Given: Cystic fibrosis (CF) is an autosomal recessive trait. Normal allele = F CF mutant…
Q: Here is a karyotype made from cancer cells. Which of the following abnormalities can be detected?…
A: A karyotype is the representation of an individual's/organism's complete set of chromosomes. These…
Q: Pedigree 1: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal…
A: pedigree 1 A. answer is... autosomal recessive B. answer is... 1 genotype is AA* 3 genotype is…
Q: An unaffected man and an unaffected woman mate and have a daughter affected with Fifimania. Which…
A: In Autosomal type of inheritance the defective allele is present on the autosomes. In sex linked…
Q: Which of the 6 modes is this pedigree and why? 1) Autosomal Dominant 2) Autosomal Recessive 3)…
A: The mode of inheritance describes how a genetic trait or disorder is passed down from generation to…
Q: Identify the mode of inheritance (either autosomal dominant, or autosomal recessive) 2. Argue why…
A:
Q: What is the most likely mode of inheritance for this trait? I 1 2 1 2 3 4 6 7 OLO 2 3 4 5 6 7 8 9 10…
A: In the given pedigree, the trait do not skip generations. This implies that the mode of inheritance…
Q: What is the mode of inheritance for the Spider Curse? (Hint: compare the children of individual Il-2…
A: Inheritance or heredity is passing on one trait from the parents to the progeny by either asexual or…
Q: Pompe disease is a glycogen storage disorder caused by a lack of ⍺-glucosidase, the enzyme that…
A: It is given that the disease is a glycogen storage disorder in which the Alpha glucosidase enzyme…
Q: What is the mode of inheritance shown in this pedigree? O a. Autosomal dominant O b. Mitochondrial O…
A: This is example of autosomal recessive disease
Q: There is ichtyosis in the family pedigree. This feature appears in each generation and is typical…
A: It is recessive X-linked ichthyosis.
Q: The pedigree shows inheritance of an autosomal recessive trait. What is the genotype of individual…
A: Need to find the genotype of individual 10. The autosomal recessive means two abnormal genes must be…
Q: Y-linked Inheritance. Holandric genes are inherited by males only. Assuming that a man with…
A: If the modified gene that causes the illness is found on the Y chromosome, one of the two sex…
Q: Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of sticky…
A: In autosomal recessive disorder, two copies of altered gene are required to cause the disease. The…
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?tion 8: below is the pedigree of inheritance of phenylketonuria (PKU). We will designate the letter Caven for the dominant allele and "p" for the recessive allele. 4 The pedigree shows that the pattern of inheritance for the allele for phenylk ylketonuria is: I. II. 1 III. IV. Autosomal dominant Autosomal recessive X-linked dominant X-linked recessive b. The parents in generation I have how many children: I. 3 Boys II. 3 Girls III. IV. 3 Boys and 1 Girl 3 Girls and 1 Boy c. What is the genotype of individual 1 in generation III: I. PP II. pp III. Pp " O 1 III. 50% E III 1 ▬ 2 2 IV. 25% 1 3 IV. Can be PP or Pp ii. Suppose that a man having type AB blood marries a woman having type O blood. What is the probability that their child will have type A blood? I. 100% II. 75% 2 4 3
- the offspring ès) can often be autosomal I 1.1 III ad amalg od no IV 9 OTO 5 0000 anivellor and goje If individual 2 were to marry a woman with no family history of the disease, which of the following would most likely be true of their children? a. All of the children would have the disease. b. None of the children would have the disease. c. Only the sons would have the disease. d. All of the sons would be carriers of the disease. e. None of the daughters would be carriers of the disease.15 1 point What is the most likely mode of inheritance of the disease depicted in the following pedigree? ||| IV 1 autosomal dominant autosomal recessive 2 N 1 2 2 3 3 4 3 4 5 --DGenetic Inheritance Patterms Retinitis pigmnentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Eric's form of RP is Usher's Syndrome, which is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. Usher's Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition. His brother, Dirk, does not have any symptoms of RP. Question below - short answer approach Imagine you are a genetics counselor, and Dirk, Erik's brother, comes in to see you. Based on his parents, what are Dirk's possible genotypes for RP? What advice would you give Dirk about the chances of Dirk's children having retinitis pigmentosa if his wife is not a carrier? How would your advice change if his wife fully has the disease? Describe all the possibilities,…
- QUESTION 22 Consider whether the mode of inheritance for each of the pedigrees below is autosomal dominant or autosomal recessive Pedigree I Both pedigrees show autosomal dominant modes of inheritance Pedigree I is autosomal dominant while pedigree II is autosomal recessive O Pedigree I is autosomal recessive while pedigree II is autosomal dominant O Both pedigrees show autosomal recessive modes of inheritance QUESTION 23 A Pedigree II The pedigree below shows the inheritance of an X-linked recessive disorder. B TH QuersPART 3– Sex Linkage Hemophilia is a recessive sex-linked disorder in which an important clotting factor protein (Factor VIII) is not produced in a functional form. Queen Victoria was a carrier of the recessive Factor VIII allele, meaning she carried the allele but was asymptomatic. Recently, historians have discovered that she secretly had an affair with the Austrian Count Chocula, who, unbeknownst to her, was a hemophiliac. Naturally, the Royal Family fought to have this information suppressed, but it was revealed that they had many children together. 1. Using the correct allele notation, write the genotypes for Queen Victoria and Count Chocula. 2. In the Punnett Square below, show the cross between the Queen and the Count. P> PĮAll the non-shaded individuals are wild type apart from III.1. III.1 has been proven to have the causative mutation for this Autosomal Dominant condition, but they exhibit no symptoms.What is the percentage level of penetrance for the condition in the diagram?
- Could this be an autosomal dominant trait? C O yes O no Could this be an autosomal dominant trait? OO O no yesCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood. The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that:a. all children will be normal b. at least two will be normalCystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood.The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that: a. all children will be normal b. at least two will be normal