COO COO- C=0 C=0 CH, CH, ? ? - CH, CH, CH, acetyl-CoA HS-COA CO0- COO a-Ketoglutarate 2-oxoadipate

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Some bacteria use the citric acid cycle intermediate, a-ketoglutarate, plus acetyl-CoA, as the starting point for lysine biosynthesis. The first part of this biosynthetic pathway uses the same chemical strategy found in the citric acid cycle. Propose a four-step pathway for the conversion of a-ketoglutarate to 2-oxoadipate. Draw the three missing intermediates, and indicate the chemistry involved in each reaction. Include any cofactors that you think might be required for specific steps.

COO
COO-
C=0
C=0
CH,
CH,
?
? -
CH,
CH,
CH,
acetyl-CoA HS-COA
CO0-
COO
a-Ketoglutarate
2-oxoadipate
Transcribed Image Text:COO COO- C=0 C=0 CH, CH, ? ? - CH, CH, CH, acetyl-CoA HS-COA CO0- COO a-Ketoglutarate 2-oxoadipate
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