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Consider a peptide with the sequence Ala-Glu-Arg-Leu. Assume the ionizable groups have the pKa values listed in Table 2.1 of your text. (a) Draw the predominant ionic form of the peptide at pH 7.4. (b) Determine the net charge of the predominant form of the peptide at pH 7.4. (c) Calculate the pI of the peptide.

Consider a peptide with the sequence Ala-Glu-Arg-Leu. Assume the ionizable groups have the pKa values listed in Table 2.1 of your text. (a) Draw the predominant ionic form of the peptide at pH 7.4. (b) Determine the net charge of the predominant form of the peptide at pH 7.4. (c) Calculate the pI of the peptide.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Consider a peptide with the sequence Ala-Glu-Arg-Leu. Assume the ionizable groups have the pKa values listed in Table 2.1 of your text.
(a) Draw the predominant ionic form of the peptide at pH 7.4.
(b) Determine the net charge of the predominant form of the peptide at pH 7.4.
(c) Calculate the pI of the peptide.
TABLE 2.1 Typical pK values of ionizable groups in proteins Group Terminal a-carboxyl group Aspartic acid Glutamic acid Histidine Terminal a-amino group Cysteine Tyrosine Lysine Arginine Acid H-N H N. -N O-H O + + H -N -S -N D... H H + H H H Ilm. N=C H H H H H + N-H O N-H H Base O H C=O O 1 <=0 N. -N -NH H -S H N-C H -O sors doidw -N -Homicilidsta H Typical pK * N-H 3.1 4.1 6.0 8.0 8.3 10.9 10.8 12.5
Transcribed Image Text:TABLE 2.1 Typical pK values of ionizable groups in proteins Group Terminal a-carboxyl group Aspartic acid Glutamic acid Histidine Terminal a-amino group Cysteine Tyrosine Lysine Arginine Acid H-N H N. -N O-H O + + H -N -S -N D... H H + H H H Ilm. N=C H H H H H + N-H O N-H H Base O H C=O O 1 <=0 N. -N -NH H -S H N-C H -O sors doidw -N -Homicilidsta H Typical pK * N-H 3.1 4.1 6.0 8.0 8.3 10.9 10.8 12.5
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