CH3 но. ОН CH3 Но. OH d. H3C H3C CN е. CH3 H3C. CH3 `CH3 OH OH f. OH o-CH3 -CH3 ОН НО HO НО HO OH OH OH

Synthesis. Developments in medicine follows advances in synthetic chemistry. Anyone that disagrees would perhaps be well served to imagine the state of surgery if organic chemists had not developed local anesthetics. The following structure is the free base of hexylcaine (1), a local anesthetic developed by Merck. Propose a synthesis of 1 starting (1) from benzene and acyclic components containing five carbons or less. Justify any chemo-, regio- or stereo selective steps in your synthesis. (

Propanal and propanone react in a similar way with acidified aqueous potassium cyanide, KCN.  For this reaction to occur reasonably quickly, the pH of the solution should be approximately 4. The reaction of propanal proceeds with acidified potassium cyanide proceeds more rapidly than that of propanone. Referring to the mechanism of the reactions, explain this phenomenon.

Show how acid derivatives hydrolyze to carboxylic acids under either acidic or basicconditions. Explain why some acid derivatives (amides, for example) require muchstronger conditions for hydrolysis than other derivatives.

Suggest a strategy for converting 1-methylcyclohexene into 1-cyclohexylmethanol. Provide the structures for the major organic products frormed in each step.

The academic version of the process invention program (PIP) contains several examples, as follows: HDAl-hydrodealkylation of toluene to produce benzene CYHEXl-cyclohexane production by hydrogenation of benzene STYRl-styrene production from ethylbenzene XYLl-production of m-xylene from toluene ANHYDl-reaction of acetone and acetic acid to form acetic anhydride BUTALl-alkylation reaction of butene-1 and isobutane to produce iso-octane Select the “new plant design” mode and the “look at existing flow sheet” option, and follow the synthesis steps for one of these processes. ‘Obtain the current flow sheet as output at each level of the synthesis procedure. Also list the heuristics used at each step.