Synthesis. Developments in medicine follows advances in synthetic chemistry. Anyone that disagrees would perhaps be well served to imagine the state of surgery if organic chemists had not developed local anesthetics. The following structure is the free base of hexylcaine (1), a local anesthetic developed by Merck. Propose a synthesis of 1 starting from benzene and acyclic components containing five carbons or less. Justify any chemo-, regio- or stereo selective steps in your synthesis. ( (1)

Question 9 of 9 Choose the best set of conditions for a Friedel-Crafts acylation of aromatic compounds. A) CH;C(O)CI, AICI3 B) CH3C(O)CI C) CH;C(O)CI, NaCI D) CH3C(O)CI, Cl2, H2O

Within each structure, rank the indicated nitrogens by increasing basicity. Explain all (guide line: Increasing basicity. Begin by identifying the classification of the nitrogen.) (b) nicotine cyamemaine, an anti-psychotic drug Pentenyl cation Pentenyl anion (d) HN LY (a) C₂H₂CH-N-C,H, LSD CH₂0. Which of these belong to MO of Vin ,t-pentadienyl? Ponlenyl radical CH₂ H (e) CH-C) HN utabrine (anti-malarial) ipsapirone, an anxiolytic drug 8888 81818 - Which of these belong to HOMO in ,,-heptatrienyl radical? And how many electron/s it has? two e, one e two e, one e, - Construct a qualitative MO diagram for the following systems and discuss how the MOS are modified by addition of the substituent (each ¹ mark) a) CH=CH-CH=CH compared to CH=CH-CHO Acrolein (propenal) NET₂ NHỊCH, b) CH=CH-CN compared to CH=CH-COOH c) CH=CH-F compared to CH=CH-NH - Comparing FMO of the given compounds with each other while doing reaction with a nucleophile and electrophile a) CH=CH-CH=CH, compared to CH=CH-CHO…

Propose a synthesis of 4-chloro-3-nitrobenzoic acid from toluene

Compound B of molecular formula C9H19N shows a noteworthy infrared absorption at 3300 cm-1. Its 1H-NMR spectrum shows three singlets – δ 1.0 (6H), 1.1 (12H), 1.4 (1H) ppm. Its 13C-NMR spectrum has four signals – δ 25, 28, 41, 64 ppm. Suggest a structure for this compound.   Please show work.

Spirocyclic compounds, such as compound 3, are made and used by insects for the purposes of communication. The first step of a synthesis of compound 3 involves treatment of (S)-1,2-epoxypropane (compound 1) with lithium acetylide, followed by acid workup, to give compound 2, as shown below (J. Org. Chem. 2005, 70, 3054-3065). Identify the structure of compound 2 and provide a mechanism for its formation. (Hint: The carbon-lithium bond reacts in a way that is similar to the carbon-magnesium bond of a Grignard reagent.) 1 13.17 a 1) Li—= 2) H₂O+ нас!!!!!! C5H8O Edit Drawing 2 Ž Modify the given structure of the starting material to draw the major product. an 3